Abstract

Desmoplastic ameloblastoma (DA) is a rare histological variant of ameloblastoma characterized by unique radiographic and histologic features. It is distinguished by unique clinical, radiological, and histopathological features. This article reports a case of Desmoplastic Ameloblastoma in a 35-year old male patient with a slow growing painless swelling in the right anterior maxillary region. Computed tomography scans shows a well defined, possibly multilocular, expansile, non corticated, isodense, non odontogenic space occupying the lesion of the right anterior maxilla. That does not cross the midline. The present case is special because of the unfamiliar appearance, potentially aggressive nature and high chances of misdiagnosis of the tumor. A surgical enucleation and curettage with peripheral ostectomy was performed. Although this variant occurs rarely a differential diagnosis of the same must be taken into consideration. While previously considered less aggressive, recent evidence suggests DA can exhibit locally destructive behavior and recurrence rates comparable to other ameloblastoma types, necessitating careful surgical management and long-term follow-up

• 1.   Bai J.K., Sonia, Midhun N., Divyasree M., Aravind Kumar S., Poornima P. Desmoplastic ameloblastoma in maxilla mimicking fibroosseous leison: A case report. Indian J Microbiol Res. 2021; 8(4): 333-6
• 2.   Sharma A., Ingole S., Deshpande M., Meshram D. Retrospective analysis of desmoplastic ameloblastoma: clinical review. Med Oral Patol Oral Cir Bucal. 2021 Mar 1; 26(2): e246-e255.
• 3.   Patil S.K., Telagi N., Nair M.R., Mujib B.R.A. Desmoplastic ameloblastoma: A case report. J Fam Med Prim Care. 2020 May; 9(5): 2544-7.139 IJDE, Volume 18 Number 3, September-December 2025
• 4.   Savithri V., Janardhanan M., Suresh R., Kumar R.V. Desmoplastic ameloblastoma with osteoplasia: review of literature with a case report. J Oral Maxillofac Pathol. 2013 May; 17(2): 298-301.
• 5.   Sun Z.J., Wu Y.R., Cheng N., Zwahlen R.A., Zhao Y.F. Desmoplastic ameloblastoma—a review. Oral Oncol. 2009 Sep; 45(9): 752-9.
• 6.   Li B., Long X., Wang S., Cheng Y., Chen X. Clinical and radiologic features of desmoplastic ameloblastoma. J Oral Maxillofac Surg. 2011 Aug; 69(8): 2173-85.
• 7.   Koh K.J., Park H.N., Kim K.A. Desmoplastic variant of ameloblastoma of the maxilla: A case report. Imaging Sci Dent. 2015 Dec; 45(4): 241- 5. doi: 10.5624/isd.2015.45.4.241. Epub 2015 Dec 17.
• 8.   Nair P.P., Bhat G.R., Neelakantan S., Chatterjee R. Desmoplastic ameloblastoma of mandible. BMJ Case Rep. 2013 Sep 17; 2013:. bcr2013200082.
• 9.   Astekar M., Rao R., Sanjai K., Sundaragiri K.S., Sapra G., Sanjeevareddygari S., Natarajan S., Odedra S.P. Desmoplastic ameloblastoma: A multicentric study of 18 case series with literature review. Medical Report. 2025; 9: 100148
• 10.   Chrcanovic B.R., Gomes C.C., Gomez R.S. Desmoplastic ameloblastoma: A systematic review of the cases reported in the literature. Int J Oral Maxillofac Surg. 2020 Jun; 49(6): 709-16.
• 11.   Lamichhane S.L., Liu Q., Sun H., et al. A case report on desmoplastic ameloblastoma of anterior mandible. BMC Res Notes. 2016; 9: 171.
• 12.   Philipsen H.P., Ormiston I.W., Reichart P.A. The desmo- and osteoplastic ameloblastoma. Histologic variant or clinicopathologic entity? Case reports. Int J Oral Maxillofac Surg. 1992 Dec; 21(6): 352-7.

Data Sharing Statement

Funding