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Comparison of Ropivacaine with Clonodine Versus Ropivacaine alone in Supraclavicular Block: A Randomised Study

Archana R Endigeri , Srinivasa R1 , Archana R Endigeri2 , Ramesh I Koppal3 , Shivanand Hulakund4

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Indian Journal of Anesthesia and Analgesia 6(2):p 369-378, MARCH-APRIL 2019. | DOI: http://dx.doi.org/10.21088/ijaa.2349.8471.6219.1

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Srinivasa R, Archana R Endigeri, Ramesh I Koppal et. al. Comparison of Ropivacaine with Clonodine Versus Ropivacaine alone in Supraclavicular Block: A Randomised Study. Indian J Anesth Analg. 2019;6(2):369-378.

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Abstract

Introduction: Ropivacaine is a new local anesthetic agent with minimal cardiovascular toxicity. Various adjuvant have been tried with local anesthetics to prolong post operative analgesia, clonidine is one such drug. The aim of our study was to evaluate the effect of adding clonidine to ropivacaine on brachial plexus block characteristics, post operative analgesia and complications. Materials and methods: A controlled prospective clinical study was carried out among 60 patients of either gender belonging to ASA I and II undergoing upper limb surgeries. Patients were randomly allocated to either of the 2 groups of 30 each. Group- R received: Inj. Ropivacaine 35 ml (0.75%) +Inj. Normal saline 1 ml. Group-RC received Inj. Ropivacaine 35 ml (0.75%) +inj. Clonidine 1 ml (150 µg). Results: The mean time for Onset of the sensory block was 10.06 ± 35.43 minutes in group-R and 11.86 ± 65.21 minutes in group-RC (P<0.05). The mean time for Onset of the motor block was 11.96 minutes in group-R and 13.93 minutes in group-RC (P >0.5). The total duration of sensory block was 10.03 ± 1.1 hours in group R and 13.96 ± 0.69 hours in group RC, the p < 0.01. The total duration of post operative analgesia was 11.62 hours in group R and 14.57 hours in group RC, the p value being < 0.001. Conclusion: Thus we conclude from our study that addition of Clonidine 150 µgm to ropivacaine in supraclavicular brachial plexus block improves post operative analgesia without any side effects.

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Srinivasa R, Archana R Endigeri, Ramesh I Koppal et. al. Comparison of Ropivacaine with Clonodine Versus Ropivacaine alone in Supraclavicular Block: A Randomised Study. Indian J Anesth Analg. 2019;6(2):369-378.

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DOI: http://dx.doi.org/10.21088/ijaa.2349.8471.6219.1

Keywords

Ropivacaine; Clonidine; Supraclavicular; Sensory; Motor etc.

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