Home > Journals > Indian Journal of Anesthesia and Analgesia

Indian Journal of Anesthesia and Analgesia

Submit your article Read this Journals View all journals
Full Text (PDF)
Original Article

Comparison of Oral Melatonin and Clonidine Premedication on Isoflurane Consumption and Postoperative Analgesia

Nethra SS , Ranjitha Gangadharaiah1 , Nethra SS2 , Sudheesh K3 , Devika Rani4 , Satheesha5

Author Information

Licence:



Indian Journal of Anesthesia and Analgesia 6(5):p 1784-1792, September-October 2019. | DOI: http://dx.doi.org/10.21088/ijaa.2349.8471.6519.42

How Cite This Article:

Ranjitha Gangadharaiah, Nethra SS, Sudheesh K et al. Comparison of Oral Melatonin and Clonidine Premedication on Isoflurane Consumption and Postoperative Analgesia. Indian J Anesth Analg. 2019;6(5 P-II):1784-1792.

Timeline

Received : N/A         Accepted : N/A          Published : N/A

Abstract

Background: Premedication with oral melatonin and clonidine reduces anxiety and prolongs the postoperative analgesia. But there are few studies that have observed the isoflurane consumption when they are given as premedication, hence this study was conducted to compare the isoflurane consumption and duration of analgesia when oral melatonin and clonidine is given as premedication. Methods: Eighty-four patients whose aged between 18 and 60 years of American Society of Anesthesiologists one and two, undergoing surgery under general anesthesia were randomly allocated into three groups of 28 each. Group C received placebo (sugar pellet), Group M melatonin 3 mg orally and Group Cl clonidine 100 μg orally 60 min before surgery. Results: The end tidal isoflurane concentration at 30 min [Group C 0.78 (0.21), Group M 0.48 (0.15), Group Cl 0.64 (0.16) (p < 0.001)], at 60 min [Group C 0.75 (0.16), Group M 0.53 (0.2), Group Cl 0.64 (0.12) (p < 0.001 )] was lower in Group M compared to Group Cl and C. Isoflurane consumption at 30 min [Group C 6.24 (1.3), Group M 3.84 (0.75), Group Cl 4.96 (0.98) (p < 0.001)] and at 60 min [Group C 10.8 (2.18), Group M 7.65 (1.11), Group Cl 9 (2.45) (p < 0.001)] was lower in Group M compared to Group Cl and C. Duration of analgesia was 267.60 ± 81.66 min in Group C, 507.00 ± 136.11 min in group M and 438.60 ± 111.01 min in Group Cl (p < 0.001). Conclusion: Premedication with oral melatonin resulted in lower end tidal isoflurane concentration and isoflurane consumption, however it did not prolong the duration of analgesia when compared with oral clonidine.

References

No records found.


About this article

Cite this article

Ranjitha Gangadharaiah, Nethra SS, Sudheesh K et al. Comparison of Oral Melatonin and Clonidine Premedication on Isoflurane Consumption and Postoperative Analgesia. Indian J Anesth Analg. 2019;6(5 P-II):1784-1792.

Licence:



Received Accepted Published
N/A N/A N/A
DOI: http://dx.doi.org/10.21088/ijaa.2349.8471.6519.42

Keywords

Analgesia; Clonidine; Isoflurane; Melatonin

Article Level Metrics

Last Updated

Monday 13 July 2026, 15:10:31 (IST)

5656

Accesses

4
678
00

Citations


NA
NA
NA

Download citation


Article Keywords

Keyword Highlighting

Highlight selected keywords in the article text.


Timeline

Received N/A
Accepted N/A
Published N/A

licence




Access this article

Reprint Order Form
Buy this Article
Institutional Subscriptions

Share