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Comparison of Analgesic Efficacy of Oral Flupirtine Maleate and Ibuprofen in Patients Undergoing Laparoscopic Cholecystectomy: A Randomized Control Trial

Kanchan Bondarde, Senior Resident, Department of Anaesthesia and Critical Care, Grant Government Medical College & Sir J J Group of Hospitals, Mumbai 400008, Maharastra, India. , Santosh Gitte 1 , Kanchan Bondarde 2 , Mansi Gupta 3

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Indian Journal of Anesthesia and Analgesia 8(5):p 481-485, September – October 2021. | DOI: http://dx.doi.org/10.21088/ijaa.2349.8471.8521.71

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Santosh Gitte, Kanchan Bondarde, Mansi Gupta/Comparison of Analgesic Efficacy of Oral Flupirtine Maleate and Ibuprofen in Patients Undergoing Laparoscopic Cholecystectomy: A Randomized Control Trial/Indian J Anesth Analg. 2021; 8(5):481-485.
 

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Abstract

Aims and Objective: To evaluate the efficacy of Flupirtine in reducing acute postoperative pain after laparoscopic cholecystectomy as compared to Ibuprofen when administered by oral route prior to surgery and to observe and compare side effect profile of oral Flupirtine maleate and Ibuprofen. Method: This study was conducted in 60 patients of ASA1/2,21to70 years of age who were randomly divided into two groups to receive either 200mg oral flupirtine maleate or 800 mg oral Ibuprofen 2 hrs prior to the procedure. Post operatively patient was observed for vas score, RSS, rescue analgesia requirement and post-operative nausea and vomiting. Result: Patients from flupirtine group had lower VAS score than that of ibuprofen group in first 6 hours. RSS score was satisfactory in first 4 hours in flupirtine group than ibuprofen group. Rescue analgesia requirement was more in ibuprofen group than flupirtine group also post-operative nausea and vomiting was seen more in ibuprofen group than flupirtine group. Conclusion: This study concluded that, patients undergoing laparoscopic cholecystectomy, pre-emptive use of oral flupirtine 200 mg is more effective compared to oral ibuprofen 800 mg and flupirtine provides better pain relief with additional muscle relaxation and mild sedation in early post-operative period.

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Santosh Gitte, Kanchan Bondarde, Mansi Gupta/Comparison of Analgesic Efficacy of Oral Flupirtine Maleate and Ibuprofen in Patients Undergoing Laparoscopic Cholecystectomy: A Randomized Control Trial/Indian J Anesth Analg. 2021; 8(5):481-485.
 

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DOI: http://dx.doi.org/10.21088/ijaa.2349.8471.8521.71

Keywords

Laparoscopic Cholecystectomy; Flupirtine; Ibuprofen; Pre-emptive Analgesia.

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