Abstract

Materials and Methods: A total of 100 patients who fulfilled the inclusion criteria and consented were included in the randomized double blinded trial and divided into two groups; Group 1 received lignocaine combined with adrenaline nebulization and Group 2 received standard nebulized bronchodilators. The treatment response was monitored. Patient’s respiratory secretion was assessed by number of suctions for tracheal toileting per 8 hours and cough severity was assessed by Cough symptom score (CSS). Additionaly day to weaning from ventilator was documented. Data Collection: Data will be collected at baseline and regularly throughout the study period by google forms filled by care taking staff and investigators team of doctors Respiratory parameters were assessed 8th hourly followed by regular assessments and emergency intervention as and when needed were done. Statistical Analysis: We applied independent sample t-test. P-value less than 0.05, so there is a significant difference in average cough [p value of 0.0001], average secretion toileting frequency [p value of 0.0001] between loxicard and control groups. Mean of control group is always more as compare to loxicard group for average cough, average secretion and ventilator weaned days [p value of 0.0001]. Though expected, there was no gender variation among the study or control group and with a p-value of 0.27 hence statistical significance of variation among men and women were nill. Ethical Considerations: Informed consent was obtained from all participants or their legally authorized representatives. Any deterioration warranting a shift from the current medications were duly undertaken and no patient was released from the study group due to unforeseen complications. Objective: To investigate the effectiveness of Lignocaine in combination with adrenaline injury patients. Trying other combinations such as ropivacaine with or without adrenaline can be tested in the future. The findings may guide future clinical practice and research in optimizing respiratory and neurological outcomes in this specific patient population.

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