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Comparative Study of Liver Function Test Pattern in Obstructive Jaundice Due to Stones and Malignancy

Tiwari Ashutosh K , Tiwari Ashutosh K1 , Kumar Binay2 , Gaurav Mishra3 , Kar Tanushree4 , Kumar Jiwesh5

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New Indian Journal of Surgery 10(2):p 155-160, March-April 2018. | DOI: DOI: https://dx.doi.org/10.21088/nijs.0976.4747.10219.5

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Abstract

 Background: Surgical jaundice is caused by complete or partial obstruction of biliary flow. The etiology can be benign or malignant, of which the malignancies carry a grave prognosis. In rural setup of our country patients undergo conservative management for long due to shortage of advanced radiological, clinical and laboratory setup, leading to delayed referral at tertiary care centres and worsening the scenario. Diseases causing jaundice reflect as a change in liver function which can be easily assessed by simple laboratory tests. Aims & objectives: To assess the difference of liver function derangement in obstructive jaundice due to stones and malignant causes and to analyse if there is any specific pattern of liver function derangement with respect to etiology. Material and methods: A prospective descriptive study was done with 50 patients of obstructive jaundice, with group 1 (stones, n=22) and group 2 (malignancy, n= 28). Patients presenting with obstructive jaundice were subjected to clinical, laboratory and radiological evaluation and those fulfilling our criteria were assigned either group. The data was recorded and evaluation was done, using MedCalc Statistical Software. Results: The mean and highest values of total and direct bilirubin, Alkaline phosphatase, GGT, was much higher in group 2. S. albumin was significantly lower in group 2 compared to group 1. Conclusion: These parameters appear to follow a pattern as per etiology. Considering the cut off patterns, a scoring/predictive system can be developed for early diagnosis.

Keywords: Hepatic; Biliary; Pancreatic.

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DOI: DOI: https://dx.doi.org/10.21088/nijs.0976.4747.10219.5

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