Home > Journals > Indian Journal of Anesthesia and Analgesia

Indian Journal of Anesthesia and Analgesia

Submit your article Read this Journals View all journals
Full Text (PDF)
Original Article

Comparative Study between Esmolol and Xylocard for Attenuation of Pressor Responses during Laryngoscopy and Intubation

Vani N.V., Senior Resident, Dept. of Anesthesiology, Bangalore Medical Colege and Research Institute, Karnataka 560002, India. , Vani N.V.1 , Sudha B.S.2 , Niranjan Nagaraj3

Author Information

Licence:



Indian Journal of Anesthesia and Analgesia 5(4):p 638-644, April 2018. | DOI: http://dx.doi.org/10.21088/ijaa.2349.8471.5418.21

How Cite This Article:

Timeline

Received : N/A         Accepted : N/A          Published : N/A

Abstract

Background: Cardiovascular complications are one of the most common causes of anesthesiarelated morbidity and mortality.The present work was undertaken to compare the effect of lignocaine (Xylocard) with esmolol on blunting the hemodynamic responses to endotracheal intubation.

Methods: Laryngoscopy and intubation was done within 15 to 20 seconds.In group I: Inj. Lignocaine (Xylocard) i.v. was administered 3 minutes before laryngoscopy and intubation.In group II: Inj. Esmolol i.v. was administered 3 minutes before laryngoscopy and intubation. Changes in heart rate (HR), systolic blood pressure (SBP), diastolic blood pressure (DBP) and mean arterial blood pressure (MAP) were measured before induction of general anesthesia (baseline), 1, 3, and 5 min after tracheal intubation.

Results: The heart rate response between lignocaine (Xylocard) and esmolol was very significant at all times starting from 1 to 10 minutes (p ï‚£ 0.05) with esmolol showing a favorable response towards attenuation of heart rate. In systolic blood pressure, Esmolol group showed a better attenuation compared to lignocaine group (Xylocard) until 3 minutes postlaryngoscopy. Attenuation of diastolic blood pressure was significant with esmolol than with lignocaine (Xylocard) group until 3 minutes (p<0.05). In mean arterial pressure, Esmolol caused significant attenuation of pressor response (p<0.05) at 1 minute and 3 minute postlaryngoscopy.

Conclusion: Esmolol is more efficient than lignocaine (Xylocard) in attenuating the sympathetic responses to laryngoscopy and intubation.Esmolol at a bolus dose of 1.5 mg/kg i.v. administered 3 minutes before laryngoscopy appears to be very effective and should be viewed as potential treatment strategy for attenuating hemodynamic changes during induction of anesthesia.

 

 

References

No records found.


About this article

Cite this article

Licence:



Received Accepted Published
N/A N/A N/A
DOI: http://dx.doi.org/10.21088/ijaa.2349.8471.5418.21

Keywords

Esmolol; Xylocard; Laryngoscopy; Intubation; Hemodynamic; Bangalore. 

Article Level Metrics

Last Updated

Tuesday 14 July 2026, 07:43:29 (IST)

5689

Accesses

8
679
00

Citations


NA
NA
NA

Download citation


Article Keywords

Keyword Highlighting

Highlight selected keywords in the article text.


Timeline

Received N/A
Accepted N/A
Published N/A

licence




Access this article

Reprint Order Form
Buy this Article
Institutional Subscriptions

Share