Anup Kumar Roy A. Roy A. Junior Resident, Department of Emergency Medicine, Kempegowda Institute of Medical Sciences, Bengaluru, Karnataka, India
Varun Byrappa HOD and Professor, Department of Emergency Medicine, Kempegowda Institute of Medical Sciences, Bengaluru, Karnataka, India., India
Arun A. Mohanan Assistant Professor, Department of Emergency Medicine, Kempegowda Institute of Medical Sciences, Bengaluru, Karnataka, India., India
Shreyas Satish Assistant Professor, Department of Emergency Medicine, Kempegowda Institute of Medical Sciences, Bengaluru, Karnataka,, India
Kishore null Junior Resident, Department of Emergency Medicine, Kempegowda Institute of Medical Sciences, Bengaluru, Karnataka,, India
Kushanth P Senior Resident, Department of Emergency Medicine, Kempegowda Institute of Medical Sciences, Bengaluru, Karnataka,, India
Sangamesh Mustare Junior Resident, Kempegowda Institute of Medical Sciences., Kims PG Residential Quarters, VV Puram, KR Market, Bengaluru, India., India
Address for correspondence: Anup Kumar Roy A. Roy A., Junior Resident, Department of Emergency Medicine, Kempegowda Institute of Medical Sciences, Bengaluru, Karnataka, India E-mail: akroy211@gmail.com
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Byrappa V, Mohanan AA, Satish S, et al. Comparative Evaluation of Bain Circuit Versus Noninvasive Ventilation for Preoxygenation in Preventing Peri-Intubation Hypoxemia. Ind J Emerg Med. 2025;11(4):215-9.
Timeline
Received : June 12, 2025
Accepted : July 21, 2025
Published : December 30, 2025
Abstract
Introduction: Preoxygenation is a cornerstone of safe airway management, aiming to prevent hypoxemia during the apnoea associated with intubation. Efforts to optimize preoxygenation have led to the exploration of alternative techniques, such as non-invasive ventilation (NIV). The Bain circuit, a low-resistance modification
of the Mapleson D system, is commonly utilized for its effcient gas delivery to support both spontaneous and controlled ventilation. Settings and Design: Prospective observational study.
Methods and Materials: The aim was to compare the effectiveness of the Bain circuit versus NIV in preoxygenation to prevent peri-intubation hypoxemia. A prospective study was conducted among 40 subjects (20 in each of the NIV and Bain circuit groups) who were 18 years of age or older. Pregnant patients and those with diffculty in the airways, hemodynamic instability, and facial trauma were excluded. The lowest SpO2 level achieved, the time to desaturation (SpO2 < 90%), and the incidence of hypoxemia and adverse outcomes were noted in both groups
and compared. Results: The lowest SpO2 level achieved was 88.0% and 83.0% in NIV and Bain circuit groups respectively (p <0.049). Incidence of hypoxemia was higher in the Bain circuit group than the NIV group (15.0% v 5.0%; p <0.049). Time to
desaturation during intubation was found to be higher in the Bain circuit group.
Two patients (10.0%) in the Bain circuit group and one patient (5.0%) in the NIV
group developed aspiration pneumonitis during intubation.
Conclusions: Among adults undergoing tracheal intubation, preoxygenation
with NIV resulted in a lower incidence of hypoxemia during intubation than
preoxygenation with the Bain circuit.
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Data Sharing Statement
There are no additional data available. All raw data and code are available upon request.
Funding
This research received no funding.
Author Contributions
All authors contributed significantly to the work and approve its publication.
Ethics Declaration
This article does not involve any human or animal subjects, and therefore does not require ethics approval.
Acknowledgements
We would like to express our gratitude to the patients, their families, and all those who have contributed to this study.
Conflicts of Interest
No conflicts of interest.
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Cite this article
Byrappa V, Mohanan AA, Satish S, et al. Comparative Evaluation of Bain Circuit Versus Noninvasive Ventilation for Preoxygenation in Preventing Peri-Intubation Hypoxemia. Ind J Emerg Med. 2025;11(4):215-9.
This license enables reusers to distribute, remix, adapt, and build upon the material in any medium or format for noncommercial purposes only, and only so long as attribution is given to the creator.
This license enables reusers to distribute, remix, adapt, and build upon the material in any medium or format for noncommercial purposes only, and only so long as attribution is given to the creator.