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Case Report

A Rare Case of Hypercoagulable State Due to Combined Inherited Thrombophilia Protein C & S Deficiency and Possible Anti Phospholipid Syndrome Complicated by a Pulmonary Embolism Causing Cardiac Strain

Paayal Bhattacharya, Anoop Purkayastha

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Indian Journal of Emergency Medicine 11(4):p 283-288, Oct - Dec. 2025. | DOI: https://doi.org/10.21088/ijem.2395.311X.11425.13

How Cite This Article:

Bhattacharya P, Purkayastha A. A Rare Case of Hypercoagulable State Due to Combined Inherited Thrombophilia Protein C & S Deficiency and Possible Anti Phospholipid Syndrome Complicated by a Pulmonary Embolism Causing Cardiac Strain. Ind J Emerg Med. 2025;11(4):283-8.

Timeline

Received : April 28, 2025         Accepted : June 17, 2025          Published : December 30, 2025

Abstract

This is case report of a 31 year old male patient who came to emergency department with complaints of sudden onset shortness of breath associated with cardinal signs of cardiac strain followed on to be diagnosed with combined inherited thrombophilia due to protein S and protein C deficiency along with a possible antiphospholipid syndrome (APS). The case was complicated by pulmonary embolism with cardiac strain as indicated by grossly elevated NT-ProBNP and 2D Echo changes like global LV Hypokinesia and PASP of 60mmHg


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Data Sharing Statement

There are no additional data available. All raw data and code are available upon request.

Funding

This research received no funding.

Author Contributions

All authors contributed significantly to the work and approve its publication.

Ethics Declaration

This article does not involve any human or animal subjects, and therefore does not require ethics approval.

Acknowledgements

We would like to express our gratitude to the patients, their families, and all those who have contributed to this study.

Conflicts of Interest

No conflicts of interest in this work.


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Cite this article

Bhattacharya P, Purkayastha A. A Rare Case of Hypercoagulable State Due to Combined Inherited Thrombophilia Protein C & S Deficiency and Possible Anti Phospholipid Syndrome Complicated by a Pulmonary Embolism Causing Cardiac Strain. Ind J Emerg Med. 2025;11(4):283-8.


Licence:

Attribution-Non-commercial 4.0 International (CC BY-NC 4.0)

This license enables reusers to distribute, remix, adapt, and build upon the material in any medium or format for noncommercial purposes only, and only so long as attribution is given to the creator.


Received Accepted Published
April 28, 2025 June 17, 2025 December 30, 2025

DOI: https://doi.org/10.21088/ijem.2395.311X.11425.13

Keywords

Hypercoagulable stateProtein C deficiency• Hypercoagulable state • Protein C deficiency • Protein S deficiency • InheritedProtein S deficiencyInherited thrombophiliaAntiphospholipid syndrome (APS)Pulmonary embolismCardiac strain

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Received April 28, 2025
Accepted June 17, 2025
Published December 30, 2025

licence


Attribution-Non-commercial 4.0 International (CC BY-NC 4.0)

This license enables reusers to distribute, remix, adapt, and build upon the material in any medium or format for noncommercial purposes only, and only so long as attribution is given to the creator.


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