A Rare Case of Hypercoagulable State Due to Combined Inherited Thrombophilia Protein C & S Deficiency and Possible Anti Phospholipid Syndrome Complicated by a Pulmonary Embolism Causing Cardiac Strain
Paayal Bhattacharya Senior Resident, Department of Emergency Medicine, Fortis Escorts Heart Institute, Okhla, New Delhi, India
Anoop Purkayastha Consultant & Head, Department of Emergency Medicine, Fortis Escorts Heart Institute, Okhla, New Delhi, India
Address for correspondence: Paayal Bhattacharya, Senior Resident, Department of Emergency Medicine, Fortis Escorts Heart Institute, Okhla, New Delhi, India E-mail: bpaayal25@gmail.com
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Bhattacharya P, Purkayastha A. A Rare Case of Hypercoagulable State Due to Combined Inherited Thrombophilia Protein C & S Deficiency and Possible Anti Phospholipid Syndrome Complicated by a Pulmonary Embolism Causing Cardiac Strain. Ind J Emerg Med. 2025;11(4):283-8.
Timeline
Received : April 28, 2025
Accepted : June 17, 2025
Published : December 30, 2025
Abstract
This is case report of a 31 year old male patient who came to emergency department with complaints of sudden onset shortness of breath associated with cardinal signs of cardiac strain followed on to be diagnosed with combined inherited thrombophilia due to protein S and protein C deficiency along with a possible antiphospholipid syndrome (APS). The case was complicated by pulmonary embolism with cardiac strain as indicated by grossly elevated NT-ProBNP and 2D Echo changes like global LV Hypokinesia and PASP of 60mmHg
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Data Sharing Statement
There are no additional data available. All raw data and code are available upon request.
Funding
This research received no funding.
Author Contributions
All authors contributed significantly to the work and approve its publication.
Ethics Declaration
This article does not involve any human or animal subjects, and therefore does not require ethics approval.
Acknowledgements
We would like to express our gratitude to the patients, their families, and all those who have contributed to this study.
Conflicts of Interest
No conflicts of interest in this work.
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Bhattacharya P, Purkayastha A. A Rare Case of Hypercoagulable State Due to Combined Inherited Thrombophilia Protein C & S Deficiency and Possible Anti Phospholipid Syndrome Complicated by a Pulmonary Embolism Causing Cardiac Strain. Ind J Emerg Med. 2025;11(4):283-8.
This license enables reusers to distribute, remix, adapt, and build upon the material in any medium or format for noncommercial purposes only, and only so long as attribution is given to the creator.
Hypercoagulable stateProtein C deficiency• Hypercoagulable state • Protein C deficiency • Protein S deficiency • InheritedProtein S deficiencyInherited
thrombophiliaAntiphospholipid syndrome (APS)Pulmonary embolismCardiac strain
This license enables reusers to distribute, remix, adapt, and build upon the material in any medium or format for noncommercial purposes only, and only so long as attribution is given to the creator.
Esophagogastroduodenoscopy image showing esophageal mucosa with large varices
Description: No description available.
USG Doppler abdomen/hepatobiliary suggestive of Portal and Splenic Vein thrombosis
Description: No description available.
CT Abdomen & Pelvis axial view shows thrombosis of the Portal (yellow arrows) and Splenic (blue arrows) veins along with splenomegaly, and without any signs of cirrhosis
Description: No description available.
CT Abdomen & Pelvis coronal view shows thrombosis of the Portal (yellow arrows) and Splenic (blue arrows) veins, splenomegaly, and no signs of cirrhosis
Description: No description available.
The patient’s coagulation profile shows low Free Protein S and Protein C levels