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Comparative Clinical Study of Clonidine and Fentanyl as Adjuvant to Intrathecal Ropivacaine for Lower Limb Orthopaedic Surgeries

Tripti Vatsalya , Ajeet Jyotipurkar1 , Tripti Vatsalya2

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Indian Journal of Anesthesia and Analgesia 6(2):p 529-534, MARCH-APRIL 2019. | DOI: http://dx.doi.org/10.21088/ijaa.2349.8471.6219.25

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Ajeet Jyotipurkar, Tripti Vatsalya. Comparative Clinical Study of Clonidine and Fentanyl as Adjuvant to Intrathecal Ropivacaine for Lower Limb Orthopaedic Surgeries. Indian J Anesth Analg. 2019;6(2):529-534.

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Received : N/A         Accepted : N/A          Published : N/A

Abstract

Backround and Aims: Effectiveness of Ropivacaine in spinal anaesthesia for hemodyanamic stability and anaesthesia quality for lower limb orthopaedic surgeries when used with adjuvants also improves the quality of anaesthesia & analgesia. Methods: Seventy patients ASA I or II received intrathecal injection isobaric ropivacaine (0.5%) with adjuvant. Group RC (n=35) received 15 mg isobaric ropivacaine (0.5%) with 60 mcg clonidine. Group RF (n=35) received 15 mg isobaric ropivacaine (0.5%) with 25 mcg fentanyl. The onset and duration of sensory & motor block, hemodyanamic parameters were recorded. Statistical analysis was done using Statistical Package of Social Science (SPSS Version 20; Chicago Inc., USA). Results: Sensory block duration (in seconds) in RC (329.42 ± 33.86) RF(226 ± 46.98) and motor block in RC (248.51 ± 55) RF (212.60 ± 43.52) out lasted duration of surgery (125.61 + 64.46). In clonidine group, there was significant prolongation of sensory block (p < 0.001), motor block (p < 0.01) and the total analgesia time (p < 0.001). Hypotension and bradycardia occurred in 8.6% patients in clonidine group, whereas pruritus was experienced by 8.6% patients in fentanyl group. Conclusion: clonidine or fentanyl when added to ropivacaine provided adequate subarachnoid block for lower limb orthopaedic surgeries, where clonidine was better than fentanyl, in terms of duration of subarachnoid block and postoperative analgesia.

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Ajeet Jyotipurkar, Tripti Vatsalya. Comparative Clinical Study of Clonidine and Fentanyl as Adjuvant to Intrathecal Ropivacaine for Lower Limb Orthopaedic Surgeries. Indian J Anesth Analg. 2019;6(2):529-534.

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DOI: http://dx.doi.org/10.21088/ijaa.2349.8471.6219.25

Keywords

Ropivacaine; Clonidine; Fentanyl; Lower Limb Orthopaedic Surgery.

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