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Comparative Analysis of Oral Clonidin against Oral Midazolam as Premedication in Adults

Ram Nandan Prasad, Associate Professor, Department of Anesthesia, Mahatma Gandhi Institute of Medical Sciences, Sevagram, Wardha, Maharashtra 442102, India. , Ram Nandan Prasad1 , Abhikumar Shingala2

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Indian Journal of Anesthesia and Analgesia 5(6):p 1004-1008, June 2018. | DOI: http://dx.doi.org/10.21088/ijaa.2349.8471.5618.20

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Abstract

Introduction: The comparison was made between the clonidine 200 ug and midazolam 15 mg to check the clinical efficacy in respect to the sedative, attenuation of hemodynamics, anxiolytic and antisialogogue response in adult patient undergoing general anesthesia.

Material and Methods: Total of 100 patients were included in the study, included patient belong ASA 1-2 physcial status and the age group of 20 – 50 years. Males and females, both genders were included in the study. Of the total 100 patients; they were randomly divided into two groups with 50 patients in each group. Patients included in the group 1 were given Oral clonidine 200 ug, 90 mins prior to the surgery. Patients included in the group 2 were given oral midazolam 15 mg, 90 mins prior to the surgery. General  anesthesia with thiopentone sodium, vecuronium, fentanyl, oxygen, nitrous oxide and sevoflurane were given to all the patients. Five point sedation score was used to assess the patient’s level of sedation. We recorded the baseline values before medication and 90 mins after medication. After intubation period of 1, 5 and 10 mins the hemodynamic parameters were recorded.

Results: The extent of sedation was seen in the patient given Midazolam as compared to the clonidine pretreated patients. In the clonidine group we see the antisialogogue effect. In the clonidine group all the haemodynamic parameters were well maintained throughout the period of study.

Conclusion: There was significant attenuation of pressor response to laryngoscopy and intubation in the clonidine group as compared to midazolam therefore drug of choice for premedication.

 

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DOI: http://dx.doi.org/10.21088/ijaa.2349.8471.5618.20

Keywords

Clonidine; Laryngoscopy; Midazolam; Premedication.

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