Home > Journals > Indian Journal of Anesthesia and Analgesia

Indian Journal of Anesthesia and Analgesia

Submit your article Read this Journals View all journals
Full Text (PDF)
Original Article

Clonidine, Fentanyl or their Combination for Postoperative Epidural Analgesia in Lower Limb Surgeries: Comparative Study

Archana K.N., Professor, Department of Anesthesiology, JSS Medical College and Hospital, Mysore, Karnataka 570015, India. , Girish B.K.1 , Archana K.N.2 , Madhurya C.H.3 , Gurudatt C.L.4

Author Information

Licence:



Indian Journal of Anesthesia and Analgesia 5(10):p 1623-1630, Oct 2018. | DOI: http://dx.doi.org/10.21088/ijaa.2349.8471.51018.7

How Cite This Article:

Timeline

Received : N/A         Accepted : N/A          Published : N/A

Abstract

  Background: Prolonged post­operative analgesia helps in early ambulation and prevents chronic post­surgical pain. Hence, effectiveness of using a combination of two adjuvants with ropivacainefor epidural analgesia is required to be known. Objectives: To compare the effectiveness, duration of post­operative analgesia and side effects of fentanyl and clonidine used alone with ropivacaine or in combination. Materials and Methods: 105 American Society of Anaesthesiologists physical statusclass1 and 2 patients with 18 to 70 years of age posted for elective lower limb surgeries under combined spinal epidural technique were randomly assigned into 3 equal groups. Surgery was done under spinal anaesthesia and postoperatively, Group RC received 8ml 0.2% Ropivacaine + Clonidine 60mcg, Group RF received 8ml 0.2% Ropivacaine
+ Fentanyl 75mcg and Group RFC received 8ml 0.2% Ropivacaine + Clonidine 30mcg + Fentanyl 37.5mcg epidurally. The Visual Analogue Scores, onset of analgesia, peak effect of analgesia, duration of analgesia, haemodynamic parameters and side effects in each group were recorded and statistically analysed with p<0.05 considered as significant. Results: Group RFC had faster onset of analgesia, earlier peak analgesic effect and longer duration of analgesia compared to group
RC and RF. VAS scores were comparable between group RC and RFC. No statistically significant difference between the groups was noted with respect to haemodynamic parameters. Only one patient had nausea and vomiting in group RFC. Conclusion: Both clonidine and fentanyl can be used as adjuvants in lower doses without compromising the analgesic efficacy and also lower the incidence of side effects.

References

No records found.


About this article

Cite this article

Licence:



Received Accepted Published
N/A N/A N/A
DOI: http://dx.doi.org/10.21088/ijaa.2349.8471.51018.7

Keywords

Postoperativeanalgesia; Epidural; Ropivacaine; Fentanyl; Clonidine

Article Level Metrics

Last Updated

Monday 13 July 2026, 11:08:46 (IST)

5651

Accesses

6
678
00

Citations


NA
NA
NA

Download citation


Article Keywords

Keyword Highlighting

Highlight selected keywords in the article text.


Timeline

Received N/A
Accepted N/A
Published N/A

licence




Access this article

Reprint Order Form
Buy this Article
Institutional Subscriptions

Share