Home > Journals > Indian Journal of Emergency Medicine

Indian Journal of Emergency Medicine

Submit your article Read this Journals View all journals
Full Text (PDF)
Original Article

Clinicopathological Correlation of Pancytopenia

Sasidharan P.K** , Dipin Kumar P.U.* , Sasidharan P.K** , Mohamed Shaan***

Author Information

Licence:



Indian Journal of Emergency Medicine 2(2):p 101-104, July - December 2016. | DOI: DOI: http://dx.doi.org/10.21088/ijem.2395.311X.2216.2

How Cite This Article:

Timeline

Received : N/A         Accepted : N/A          Published : N/A

Abstract

 Objectives: Increasing number of patients present now a days with pancytopeniadue to B12 and folic acid deficiencies, bone marrow failures and hypersplenism. The changing diet, lifestyle, and environment could be the cause for the increased incidence. It is important to have a clinical diagnosis at presentation itself, to identify and treat the potentially correctable causes of pancytopenia like vitamin B12 deficiency. The present study was to look into the correlation between clinical diagnosis and final diagnosis; and also to study the clinical profile, etiological factors,and treatment response in the subgroup of patients diagnosed to have B12/folate deficiency. Methods: It was a cross-sectional study involving 65patients in one year. Their clinical diagnosis (made after history, physical examination and hemogram) was compared with the final diagnosis. The subgroup of patients diagnosed to have B12/folate deficiency was studied in detail for their clinical profile & etiological factors. Results: There was a statistically significant correlation between clinical & final diagnosis. Sensitivity of clinical diagnosis was highest (93%) for B12/folate deficiency. Diet history, knuckle pigmentation, glossitis and MCV>100fl had a statistically significant association with B12/folate deficiency. Conclusions: B12/folate deficiency and acute leukemia were the commonest causes for pancytopenia. Sensitivity of clinical and pathological diagnoses of B12 deficiency was 93% and 73% respectively. Hence high clinical suspicion is mandatory for diagnosis of vitamin B12 deficiency. The diagnosis of vitamin B12/folate deficiency can be predicted using the dietary history, knuckle pigmentation, glossitis and MCV>100fl.

Keywords: Pancytopenia; B12 Deficiency; Folic Acid Deficiency; ClinicoPathological Correlation.

References

No records found.


About this article

Cite this article

Licence:



Received Accepted Published
N/A N/A N/A
DOI: DOI: http://dx.doi.org/10.21088/ijem.2395.311X.2216.2

Keywords


Article Level Metrics

Last Updated

Sunday 21 June 2026, 22:40:56 (IST)

2182

Accesses

3
767
00

Citations


NA
NA
NA

Download citation


Article Keywords

Keyword Highlighting

Highlight selected keywords in the article text.


Timeline

Received N/A
Accepted N/A
Published N/A

licence




Access this article

Reprint Order Form
Buy this Article
Institutional Subscriptions

Share