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Association of Cleft Palate and Ankyloglossia

Ravi Kumar Chittoria, Head, Department of Plastic Surgery, Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER) Pondicherry 605006, India. , Kumaran M.S.a , Chittoria R.K.b , Pandey S.a , Bibilash B.S.a , Friji M.T.c , Mohapatra D.P.c , Dinesh K.S.c , Sudhanva H.K.a , Preethitha B.a

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New Indian Journal of Surgery 9(1):p 7-9, Jan-Feb 2018. | DOI: https://dx.doi.org/10.21088/nijs.0976.4747.9118.1

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Abstract

Clefts of the lip and/or palate are among the most common birth defects worldwide [1]. The majority are nonsyndromic where cleft lip and palate occurs in isolation of other phenotypes. Where one or more additional features are involved, clefts are referred to as syndromic. Collectively cleft palate has a major clinical impact requiring surgical, dental, orthodontic, speech, hearing and psychological treatments or therapies throughout childhood. The etiology of cleft palate seems complex, with genetics playing a major role. Several genes causing syndromic cleft palate have been discovered. The etiological complexity of nonsyndromic cleft lip and palate is also exemplified by the large number of candidate genes and loci. To conclude, although the etiology of nonsyndromiccleft palate is still largely unknown, mutations in candidate genes have been identified in a small proportion of cases. We present a case of syndromic cleft palate with ankyloglossia

 

 

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DOI: https://dx.doi.org/10.21088/nijs.0976.4747.9118.1

Keywords

Cleft Palate; Ankyloglossia; Tbox Transcription Factor22. 

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