Abstract

Background: Abnormal menstrual patterns are many times associated with thyroid dysfunction which is yet an under evaluated cause. Objective: This study aims to determine the association between abnormal uterine bleeding (AUB) and thyroid dysfunction. Materials and methods: This prospective, single-center, cross sectional analytical study was conducted with all women who were attended with AUB at investigation site. In total, 256 women were enrolled in study. Those with diagnosed thyroid dysfunction were excluded from the study. After assessment of the menstrual pattern, all women were subjected for Abdomino-pelvic ultrasonography and blood tests hemogram and thyroid profile. The women were divided into these categories based on thyroid values: Euthyroid, hyperthyroid, subclinical hypothyroidism and hypothyroid. Results: In this study, the average age of women was 41.48 years. Out of a total of 256 individuals, the majority (62.1%) were found to be euthyroid, indicating normal thyroid function. Hypothyroidism was observed in 29.3% of the women, while hyperthyroidism accounted for 6.3%. A smaller proportion (2.3%) exhibited subclinical hypothyroidism. The most frequent complaint was heavy menstrual bleeding (HMB), reported by 160 individuals, predominantly among those with euthyroidism (61.3%) and hypothyroidism (33.1%). Metrorrhagia occurred in only three cases, two of which were in individuals with hypothyroidism (66.7%). Isolated thyroid dysfunction was present in 15.6% of the study population, which is significant. Conclusions: Hypothyroidism was significantly associated to HMB. Most women were euthyroid, but altered thyroid function, especially hypothyroidism, influenced menstrual irregularities in a substantial subset. There is need to shed light on isolated thyroid dysfunction.

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