Abstract

Oral cancer may arise de-novo or may be preceded by Oral Potentially Malignant Disorders (OPMDs). Chemerin is multifunctional adipokine with important role in regulating angiogenesis, cell proliferation and inflammation. Chemerin expression could be helpful for evaluating the progressive risk of OPMDs like OSMF and also help in evaluating prognosis of OSCC. In the present study total 80 subjects were assessed for serum chemerin levels. Among these 20 were healthy controls and 20 cases each of OSMF, OSMF associated OSCC and OSCC. The values of serum chemerin were compared between controls and cases and also amongst the clinical stages of the study groups. our study demonstrated a progressively statistically significant increase in mean serum chemerin levels in OSMF cases, OSMF associated OSCC cases and OSCC cases than the controls. Thus serum chemerin level can be used as an adjunctive serum biomarker for predicting the malignant potential of OSMF and diagnosis of OSMF associated OSCC and OSCC.

• 1.   Ghantous Y, Elnaaj A. Global incidence and risk factors of oral cancer. Harefuah. 2017;156(10):645-649.
• 2.   Soares AB, Perschbacher K, Perez-Ordonez B. Oral potentially malignant disorders. Diagn Histopathol. 2018;24(5):161-165.
• 3.   Choudhari SK, Chaudhary M, Gadbail AR, Sharma A, Tekade S. Oxidative and antioxidative mechanisms in oral cancer and precancer: a review. Oral Oncol. 2014;50(1):10-18.
• 4.   More CB, Rao NR. Proposed clinical definition for oral submucous fibrosis. J Oral Biol Craniofac Res. 2019;9(4):311-314.
• 5.   Phulari RG, Dave EJ. A systematic review on the mechanisms of malignant transformation of oral submucous fibrosis. Eur J Cancer Prev. 2020;29(5):470-473.
• 6.   Chourasia NR, Borle RM, Vastani A. Concomitant association of oral submucous fibrosis and oral squamous cell carcinoma and incidence of malignant transformation of oral submucous fibrosis in a population of central India: A retrospective study. J Maxillofac Oral Surg. 2015;14(4):902-906.
• 7.   Ray JG, Ranganathan K, Chattopadhyay A. Malignant transformation of oral submucous fibrosis: Overview of histopathological aspects. Oral Surg Oral Med Oral Pathol Oral Radiol. 2016;122(2):200-209.
• 8.   Grivennikov SI, Karin M. Inflammatory cytokines in cancer: tumour necrosis factor and interleukin 6 take the stage. Ann Rheum Dis. 2011;70(Suppl 1):i104-108.
• 9.   Fatima SS, Rehman R, Baig M, Khan TA. New roles of the multidimensional adipokine: chemerin. Peptides. 2014;62:15-20.
• 10.   Wang N, Wang QJ, Feng YY, Shang W, Cai M. Overexpression of chemerin was associated with tumor angiogenesis and poor clinical outcome in squamous cell carcinoma of the oral tongue. Clin Oral Investig. 2014;18(3):997-1004.
• 11.   Marsh D, Suchak K, Moutasim KA, Vallath S, Hopper C, Jerjes W, et al. Stromal features are predictive of disease mortality in oral cancer patients. J Pathol. 2011;223(4):470-481.
• 12.   Kansara S, Sivam S. Premalignant lesions of the oral mucosa. InnovAiT. 2013;6(7):446-451.
• 13.   Zhou S, Li L, Jian X, Ou X, Jiang H, Yao Z, et al. The phosphorylation of survivin Thr34 by p34cdc2 in carcinogenesis of oral submucous fibrosis. Oncol Rep. 2008;20(5):1085-1091.
• 14.   Fujimoto J, Sakaguchi H, Aoki I, Tamaya T. Clinical implications of expression of interleukin 8 related to angiogenesis in uterine cervical cancers. Cancer Res. 2000;60(10):2632-2635.
• 15.   Bozaoglu K, Curran JE, Stocker CJ, Zaibi MS, Segal D, Konstantopoulos N, et al. Chemerin, a novel adipokine in the regulation of angiogenesis. J Clin Endocrinol Metab. 2010;95(5):2476-2485.
• 16.   Nishida N, Yano H, Nishida T, Kamura T, Kojiro M. Angiogenesis in cancer. Vasc Health Risk Manag. 2006;2(3):213-219.
• 17.   Kaur J, Adya R, Tan BK, Chen J, Randeva HS. Identification of chemerin receptor (ChemR23) in human endothelial cells: chemerin-induced endothelial angiogenesis. Biochem Biophys Res Commun. 2010;391(4):1762-1768.
• 18.   Ferland DJ, Watts SW. Chemerin: a comprehensive review elucidating the need for cardiovascular research. Pharmacol Res. 2015;99:351-361.
• 19.   Ekanayaka RP, Tilakaratne WM. Oral submucous fibrosis: Review on mechanisms of pathogenesis and malignant transformation. J Carcinog Mutagen. 2013;S4:002.
• 20.   Ghallab NA, Shaker OG. Serum and salivary levels of chemerin and MMP-9 in oral squamous cell carcinoma and oral premalignant lesions. Clin Oral Investig. 2017;21(3):937-947.
• 21.   Reichart PA, Philipsen HP. Oral erythroplakia—a review. Oral Oncol. 2005;41(6):551-561.

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