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Alcohol Induced Liver Cirrhosis and its Treatment

Mohit Gururani , Mohit Gururani1 , Pallavi Dheer2 , Tejpal3 , BhupendraKumar4 , Rishabh Garg5 and Narotam Sharma6

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Indian Journal of Medical and Health Sciences 7(2):p 61-70, July-December 2020. | DOI: https://dx.doi.org/10.21088/ijmhs.2347.9981.7220.8

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Abstract

The advent of liver diseases globally contributes to a major burden in terms of mortality rate and disease factor. The liver, which is a major complex organ, plays a vital role in the metabolism of the body. The diseases associated with the consumption of alcohol such as cirrhosis and cancer that can be diagnosed through various pathological and cytopathological methods. This review insights how the normally functioning liver cells become vulnerable and lead to the onset of various fatal disorders if left untreated. The alcohol, unlike other drinks, is directly absorbed from the stomach into the bloodstream and is further metabolized by the hepatocytes. The products of alcohol breakdown, such as aldehyde, are toxic to hepatocytes and thus cause liver injury, in cases of chronic alcohol consumption. This injury to the hepatocytes evolves over time and leads to liver cirrhosis. The only cure for severe liver cirrhosis is a transplant of the liver. On the whole, the widespread consumption of alcohol, its making, and effects on the hepatocytes on chronic consumption, which leads to alcoholic liver diseases reviewed.

Keywords: Hepatocytes; Fibrosis; Cirrhosis; Hepatitis, Hemochromatosis.

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DOI: https://dx.doi.org/10.21088/ijmhs.2347.9981.7220.8

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