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Addition of Dexmedetomidine as an Adjuvant to Local Anesthetic Agent in Intravenous Regional Anesthesia

Deepika Sathe , Vishwas Sathe1 , Deepika Sathe2 , Robin Gupta3 , Kanha Agrawal4

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Indian Journal of Anesthesia and Analgesia 6(6):p 2031-2040, November-December 2019. | DOI: http://dx.doi.org/10.21088/ijaa.2349.8471.6619.27

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Vishwas Sathe, Deepika Sathe, Robin Gupta et al. Addition of Dexmedetomidine as an Adjuvant to Local Anesthetic Agent in Intravenous Regional Anesthesia. Indian J Anesth Analg. 2019;6(6 Part -I):2031-2040.

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Abstract

Aims and objectives: To compare addition of dexmedetomidine as an adjuvant to local anesthetic agent in intravenous regional anesthesia. Materials and Methods: We conducted a prospective, randomized, double blind study, in which 50 patients undergoing posted for hand and forearm surgeries were enrolled for the study. Patients were randomly distributed in two Groups (25 in each Group). Group I - 25 patients were administered lignocaine (3 mg/kg) to total volume without adjuvant in IVRA. Group II - 25 patients were administered (1 mcg/kg) dexmedetomidine as an adjuvant to lignocaine (3 mg/kg) to total volume in IVRA. Results: Onset of sensory and motor block was hastened by the addition of Dexmedetomidine to local anesthetic agent.The mean time taken to achieve complete sensory block and motor block was maximum in control group as compared to Study Group. All patients in both the groups had excellent quality of surgical anesthesia, and duration of sensory and motor block was prolonged with the addition of Dexmedetomidine (1 mcg/kg) as compared to Control Group. The total duration of post-operative analgesia was highly significant with addition of Dexmedetomidine as compared to control group. Conclusion: All patients in both the Groups had excellent quality of surgical anesthesia, and duration of sensory and motor block was prolonged with the addition of Dexmedetomidine (1 mcg/kg) as compared to control group. The total duration of post-operative analgesia was highly significant with addition of Dexmedetomidine as compared to control group. Addition of Dexmedetomidine (1 mcg/kg) to lidocaine (3 mg/kg) as an adjuvant can be used safely.

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Vishwas Sathe, Deepika Sathe, Robin Gupta et al. Addition of Dexmedetomidine as an Adjuvant to Local Anesthetic Agent in Intravenous Regional Anesthesia. Indian J Anesth Analg. 2019;6(6 Part -I):2031-2040.

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DOI: http://dx.doi.org/10.21088/ijaa.2349.8471.6619.27

Keywords

Dexmedetomidine; Lignocaine; Hemodynamic responses.

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