Abstract

Acute pancreatitis is one among the common causes of pain abdomen presenting to emergency department. Some of the most common causes of acute pancreatitis include gallstones, alcohol use, hypertriglyceridemia and Drugs. Over 500 drugs are implicated as a causative agents and account for less than 2% of cases. Sodium valproate, one of the commonly prescribed anti-epileptic drug is known to cause acute pancreatitis. Here, we are presenting a case of a 26-years-old male who is a known case of juvenile myoclonic epilepsy on sodium valproate who presented with acute pancreatitis. Our reasons for highlighting this case are: To illustrate a patient with juvenile myoclonic epilepsy on sodium valproate developing acute pancreatitis with other adverse effects like gum hypertrophy, vitamin B12 and folate deficiency.

• 1.   Gardner T.B. Acute pancreatitis. Ann. Intern. Med. 2021;174:ITC17–ITC32. doi: 10.7326/ AITC202102160.
• 2.   Walkowska J., Zielinska N., Karauda P., Tubbs R.S., Kurtys K., Olewnik L. The pancreas and known factors of acute pancreatitis. J Clin. Med. 2022;11:5565. doi: 10.3390/jcm11195565.
• 3.   Barakat M.T., Abu-El-Haija M., Husain S.Z. Clinical insights into drug-associated pancreatic injury.Curr. Opin. Gastroenterol.2022;38:482–486. doi: 10.1097/MOG.0000000000000865.
• 4.   Peterson G.M., Naunton M. Valproate: A simple chemical with so much to offer. J. Clin. Pharm. Ther. 2005;30:417–421. doi: 10.1111/j.1365-2710.2005.00671.x.
• 5.   Wartman C., VandenBerg A. Valproate: Not all boxed warnings are created equal. Ann. Pharmacother. 2022;56:1349–1355. doi: 10.1177/10600280221085991.
• 6.   Genton P, Gelisse P. Vaproic acid. Adverse effects. In: Levy RH, Mattson RH, Meldrum BS, Perucca E (Eds). Antipepileptic drugs. 5th ed. Lippincott William &Wilkins, Philadelphia, 2002;838–851.
• 7.   Hamad AE, Fawzi ME. Valproate associated acute pancreatitis. Neurosciences. 2000;5(3):156–8.
• 8.   Perrott J, Murphy NG, Zed PJ. L-carnitine for acute valproic acid overdose: a systematic review of published cases. Ann Pharmacother. 2010;44(7–8):1287–93.
• 9.   Davis RB, Sunder TR, Barakat HA, May R. Valproate Alters the Membrane Phospholipids of Erythrocytes. Epilepsia. 1991;32;11-2.
• 10.   Hallmon WW, Rossmann JA. The role of drugs in the pathogenesis of gingival overgrowth. Periodontol. 2000;1999(21):176.
• 11.   Yazdani K, Lippmann M, Gala I. Fatal pancreatitis associated with valproic acid, review of the literature. Medicine. 2002;81(4):305–10.
• 12.   Hamad AE, Fawzi ME. Valproate associated acute pancreatitis. Neurosciences. 2000;5(3):156–8.
• 13.   Gerstner T, Büsing D, Bell N, Longin E, Kasper JM, Klostermann W, et al. Valproic acid-induced pancreatitis: 16 new cases and a review of the literature. J Gastroenterol. 2007;42:39–48.

Data Sharing Statement

Funding