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A Study on the Risk Factors for Increased Carotid Intima Media Thickness (Cimt) in Type-2 Diabetes Mellitus

Anand Chavan, Senior Resident, Department of General Medicine, Gadag Institute of Medical Sciences, Gadag, Karnataka 582103, India. , Ambrish Avate , Anand Chavan

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Indian Journal of Emergency Medicine 4(3):p 195-200, Jul-Sep, 2018. | DOI: http://dx.doi.org/10.21088/ijem.2395.311X.4318.15

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Abstract

One of the important mechanisms responsible for the accelerated atherosclerosis in Diabetes is the non-enzymatic reaction between glucose and proteins or lipoproteins in arterial walls collectively known as Maillard or browning reaction. Glucose forms chemically reversible early glycosylation products with reactive amino groups of circulating or vessel wall proteins (Schiff bases) which subsequently re-arrange to form the more stable Amadori-type early glycosylation products. This single centre, prospective, observational study was carried out in Diabetes unit of tertiary care hospital in patients of type 2 Diabetes Mellitus (T2DM). After the approval of institutional ethics committee, Diabetic patients attending the Diabetology unit of a tertiary care center were recruited into the study. There was significant positive correlation of CIMT with age (Pearson Correlation coefficient: 0.611, p<0.01). But with BMI, though a positive correlation was observed, it was not significant (Pearson Correlation coefficient: 0.079, p=0.437). Similarly, with WHR (4C) positive correlation was observed but it was not significant (Pearson Correlation coefficient: 0.108, p=0.284).

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DOI: http://dx.doi.org/10.21088/ijem.2395.311X.4318.15

Keywords

CIMT; BMI; Age.

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