Home > Journals > Indian Journal of Anesthesia and Analgesia

Indian Journal of Anesthesia and Analgesia

Submit your article Read this Journals View all journals
Full Text (PDF)
Original Article

A Randomized Clinical Trail to Compare Palonosetron and Ondansetron for Prevention of Post Operative Nausea and Vomiting

Dinesh Naik, Assistant Professor, Dept. of Anesthesia, S.N Medical College, Navanagar, Bagalkot, Karnataka 587102, India. , Shilpa Masur1 , Dinesh Naik2 , Abhishek H.N.3 , Vandana Gogate4

Author Information

Licence:



Indian Journal of Anesthesia and Analgesia 5(4):p 618-622, April 2018. | DOI: http://dx.doi.org/10.21088/ijaa.2349.8471.5418.18

How Cite This Article:

Timeline

Received : N/A         Accepted : N/A          Published : N/A

Abstract

Abstract: Nausea and vomiting is known to be associated with the use of anaesthetic technique for many years. Ondansetron a gold standard drug used for treatment of post operative nausea and vomiting (PONV) is short acting and multiple doses are needed. Objective of the present study is to compare the efficacy of palonosetron and ondansetron for prevention of PONV in patients undergoing abdominal surgery under general anaesthesia.

Methods: 140 patients undergoing abdominal surgery under general anesthesia were randomised and allocated into two groups after taking into consideration inclusion and exclusion criteria. Group I received ondansetron 8mg intravenously and Group II received palonosetron 0.075mg intravenously 5 min before the induction of anesthesia. In all patients general anaesthesia given using thiopentone as inducing agent. Occurrence of PONV was noted and was scored for 24 hrs.

Results: The incidence of PONV was significantly lower in the palonosetron group compared with the ondansetron group (24.3% vs 78.6%, respectively). Emetic episodes were observed in 5.71% of patients in palonosetron group compared to 61.4% of patients in ondansetron group (P value <0.001). The results were clinically and statistically significant.

Conclusion: Incidence of PONV and emetic episodes is less in patients who had received palonosetron in comparison to those who had received ondansetron. From the study we conclude that palonosetron is more efficacious than ondansetron for prevention of PONV in patients undergoing abdominal surgery under general anesthesia.

 

 

References

No records found.


About this article

Cite this article

Licence:



Received Accepted Published
N/A N/A N/A
DOI: http://dx.doi.org/10.21088/ijaa.2349.8471.5418.18

Keywords

Post Operative Nausea and Vomiting; Palonosetron; Ondansetron; General Anaesthesia. 

Article Level Metrics

Last Updated

Tuesday 14 July 2026, 07:45:54 (IST)

5689

Accesses

5
679
00

Citations


NA
NA
NA

Download citation


Article Keywords

Keyword Highlighting

Highlight selected keywords in the article text.


Timeline

Received N/A
Accepted N/A
Published N/A

licence




Access this article

Reprint Order Form
Buy this Article
Institutional Subscriptions

Share