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A Prospective Comparative Study of 0.5% Levobupivacaine versus 0.5% Ropivacaine in Supraclavicular Brachial Plexus Block

Anand Acharya, Professor and Head, Department of Pharmacology, Konaseema Institute of Medical Science, Amalapuram, Andhra Pradesh 533201, India. , V.S.S.N. Murthy1 , K. Amarnath Naik2 , Anand Acharya3

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Indian Journal of Anesthesia and Analgesia 5(8):p 1396-1400, August 2018. | DOI: http://dx.doi.org/10.21088/ijaa.2349.8471.5818.23

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Abstract

Background: Levobupivacaine is a s enantiomer of bupivacaine has been introduced in clinical practise in India, with lower cardio toxicity and neurotoxicity in comparison to bupivacaine [7,8]. We have designed present study as a prospective comparative study with an aim evaluate the onset and duration of sensory and motor block when0.5% Levobupivacaine and 0.5% ropivacaine are used for supraclavicular brachial plexus anaesthesia.

Material and Method: Present study is a randomised prospective comparative study conducted in the dept. of anaesthesia Konaseema institute of medical science Amalapuram from Sept 2015 to Feb 2018. Patients were allocated randomly into two groups using computer generated block randomization. Group A (n=40) received 30ml of 0.5% Levobupivacaine and Group B(n=40) received 30ml of 0.5% Ropivacaine. Parameters observed were onset-of sensory and motor block, duration of analgesia andrequirement of opioid supplementation.

Result: Mean sensory onset time in group A (Levobupivacaine) was 14.065 min in comparison to 16.829+5.01 mins in group B, with P value 0.172372. Mean time required for the onset of motor blocks in group A was 18.0225+6.33 min but in group B it was 21.35+5.49 with P value 0.007096. Out of forty patients four patients in group A require opioid supplementation and eight patients out of 40 patients in group B required opioid supplementation with p value 0.210406.

Discussion and Conclusion: From present study we would like to conclude that the onset of sensory and motor block was earlier in Levobupivacaine group than ropivacaine. The duration of sensory and motor block was also longer in Levobupivacaine group then ropivacaine.

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DOI: http://dx.doi.org/10.21088/ijaa.2349.8471.5818.23

Keywords

Ropivacaine; Levobupivacaine; Supraclavicular Brachial Plexus Block.

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