Home > Journals > Indian Journal of Anesthesia and Analgesia

Indian Journal of Anesthesia and Analgesia

Submit your article Read this Journals View all journals
Full Text (PDF)
Original Article

A Comparative Study of the Efficacy of Oral Gabapentin and Melatonin on Post Operative Pain and Analgesic Consumption in Patients Undergoing Modified Radical Mastectomy

Jenish Patel, Junior Lecture, Department of Anaesthesia, Gujarat Cancer and Research Institute, Ahmedabad, Gujarat 380016, India. , Priti Patel1 , Jenish Patel2 , Drishti Dave3 , Pallavi S.4 , Arun Rohit5 , Bhavna Shah6

Author Information

Licence:



Indian Journal of Anesthesia and Analgesia 5(7):p 1132-1139, July 2018. | DOI: http://dx.doi.org/10.21088/ijaa.2349.8471.5718.8

How Cite This Article:

Timeline

Received : N/A         Accepted : N/A          Published : N/A

Abstract

High levels of post operative pain and anxiety increases patient discomfort and post operative morbidity. Anxiolytic and analgesic effects of melatonin improves control of post operative pain by controlling higher anxiety that accompanies surgical intervention. This study compares antinociceptive effects of both melatonin and gabapentin premedication on post operative pain and analgesic requirement.

Methods: Ninety female patients undergoing modified radical mastectomy were randomly divided into three groups of 30 each where Group G given Gabapentin 600 mg, Group M given Melatonin 6 mg, Group C given placebo tablet 90 minutes before surgery. Post operative pain, sedation scores and post operative analgesic consumption was assessed for 24 hrs.

Results: Visual analogue scale (VAS) score were lower in the group G and group M as compared to group C. Sedation score recorded highest in Group M followed by Group G and least in Group C. Time to first analgesic requirement was 16.58±4.47 hrs in Group G, 6.09±5.12 hrs in Group M and 2.80±0.83 hr in Group C (p<0.0001). Total 24 hr post operative diclofenac requirement in Group G (96.77±34.60) was significantly lower than Group C (166.93±31.87) and M (142.74±44.81) (p<0.0001).

Conclusion: Both melatonin and gabapentin reduced post operative pain and analgesic consumption. Gabapentin had higher analgesic effect while melatonin was more sedative. Administration of melatonin before surgery may accelerate the resynchronization of circardian rhythm in the post operative period suggesting better recovery quality.



 

References

No records found.


About this article

Cite this article

Licence:



Received Accepted Published
N/A N/A N/A
DOI: http://dx.doi.org/10.21088/ijaa.2349.8471.5718.8

Keywords

Gabapentin; Melatonin; Female Patients; Post Operative Pain; Modified Radical Mastectomy.

Article Level Metrics

Last Updated

Monday 13 July 2026, 07:34:37 (IST)

5648

Accesses

7
678
00

Citations


NA
NA
NA

Download citation


Article Keywords

Keyword Highlighting

Highlight selected keywords in the article text.


Timeline

Received N/A
Accepted N/A
Published N/A

licence




Access this article

Reprint Order Form
Buy this Article
Institutional Subscriptions

Share