Indian Journal of Genetics and Molecular Research

Complement is a major component of innate immune system involved in defending against all the foreign pathogens through complement fragments that participate in opsonization, chemotaxis, and activation of leukocytes and through cytolysis by C5b- 9 membrane attack complex. The complement (C) system has been implicated as a factor in the causation or propagation of tissue injury in central and peripheral nervous system disorders. Complement factors play a predominant role in nerve injury, inflammation and repair, thus playing part in neurodegeneration, neuroinflammation and neuroprotection. 

Keywords: Immunology; Neuroimmunology; Immunogenetics; Genetic neurology; Complement system. 

Edward syndrome is a genetic disorder caused by presence of all or part of an extra 18 chromosome. It is the 2nd most common autosomal trisomy after Down syndrome. 

Keywords: Edward’s syndrome; Trisomy18; TrisomyE.

Method: The aim of present study was to assess the association of causative gene polymorphisms of ADAM33 in Asian population using Meta-analysis approach.We performed a literature search using the MEDLINE citation database and references in the identified reports. Data were analyzed using software Stata 11.2( Stata Corp, College Station, Texas, US). Thirteen studies and twelve ADAM33 gene polymorphisms were selected for meta-analysis, which included 3,270 patients and 2,922 controls. Results: On comparing data for “M” (Mutant allele) with the susceptibility to asthma as compared to the “L” (wild allele), four SNPs named as, S2, ST+5, T1 and Q-1 were observed to be associated with asthma. Likewise, on calculating “MM” (homozygous mutant genotype) vs “LL” (homozygous normal genotype), SNPs S2 and ST+5 showed association. After calculating, “LM” (heterozygous genotype) + “(MM vs LL)”, SNP ST+5 was found to be associated and lastly when we compared “MM” vs “(LL+LM)”, SNPs T1, S2 and ST+5 were found to be associated with asthma. Conclusion: To our knowledge, this is the first and most comprehensive genetic meta-analysis showing association of ADAM33 gene polymorphisms (Q-1, S2 and T1) with asthma in Asian population. 

Keywords: Asian population;  Meta-analysis; Single nucleotide polymorphisms; Association study; Case-control studies. 

The present investigation was planned on three endogamous groups of Haryana viz. Bishnoi, Sunar and Kumhar, and the distribution of serological traits like ABO and Rh (D) blood groups was determined. In the ABO blood group system the frequency of A allele ranged from 0.09-0.24, that of B allele ranged from 0.24- .40 and of O allele from 0.36-0.67. In Rh(D) blood group system the frequency of d allele ranged from 0.26-0.35 while the frequency of D allele varied from 0.65-0.74. The frequency range of traits studied conformed to the range of other populations of North West India studied earlier. 

Keywords: ABO; Allele frequency; Endogamous groups; Rh (D) blood group. 

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