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Unmasking the Mystery: A Case of Atypical Viral Encephalitis Presenting with Unusual Headache and Neurological Deterioration

Sagar V. Rati, Varun H.S, Prerana Arun, Santhosh N.S., Abha Verma, Suhas Rao, Muniraju M

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Indian Journal of Emergency Medicine 12(1):p 27-29, Jan. March 2026. | DOI: https://doi.org/10.21088/ijem.2395.311X.12126.4

How Cite This Article:

Sagar V. Rati, Varun H.S., Prerana Arun, et al. Unmasking the Mystery: A Case of Atypical Viral Encephalitis Presenting with Unusual Headache and Neurological Deterioration. Ind J Emerg Med. 2026; 12(1): 27-29.

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Received : August 04, 2025         Accepted : October 06, 2025          Published : March 30, 2026

Abstract

Headaches are a common symptom encountered in clinical practice, yet they can sometimes obscure more serious underlying conditions. This case report describes the diagnostic journey of a 52-year-old male presenting with an atypical headache, followed by progressive neurological symptoms, and initially inconclusive investigations. The diagnosis of viral encephalitis was established through cerebrospinal fluid (CSF) analysis, despite negative results for common viral pathogens. This case underscores the critical importance of maintaining a high clinical suspicion and conducting a comprehensive work-up, even in the face of normal or negative initial diagnostic findings.


References

  • 1.   Graus, F., & Titulaer, M.J. (2016). Viral encephalitis: Diagnosis and management. Journal of Neurology, Neurosurgery, and Psychiatry, 87(3), 287-294. https://doi. org/10.1136/jnnp-2015-311889
  • 2.   Tunkel, A.R., Glaser, C.A., Bloch, K.C., et al. (2008). The management of encephalitis: Clinical practice guidelines by the Infectious Diseases Society of America. Clinical Infectious Diseases, 47(3), 303-327. https:// doi.org/10.1086/589747 3.
  • 3.   Whitley, R.J., & Alford, C.A. (1999). Herpes simplex virus infections of the central nervous system. The New England Journal of Medicine, 340(20), 1501-1509. https://doi.org/10.1056/ NEJM199905203402007
  • 4.   Murray, R.W., & Doering, L.C. (2013). Encephalitis: Causes and clinical manifestations. Journal of Clinical Virology, 56(3), 155-159. https://doi.org/10.1016/j. jcv.2013.06.014
  • 5.   Levin, M., & Pennington, R. (2010).Viral encephalitis: Pathogenesis, clinical features, and management. Clinical Microbiology Reviews, 23(3), 523-539. https://doi. org/10.1128/CMR.00010-10
  • 6.   Zhang, L., & Chen, R. (2019). Cerebrospinal fluid analysis for diagnosis of viral encephalitis. The Lancet Neurology, 18(7), 709-711. https:// doi.org/10.1016/S1474-4422(19)30190-5
  • 7.   Klein, M., & Marra, C.M. (2014). Diagnostic challenges in viral encephalitis: A casebased review. Journal of Clinical Neurology, 10(4), 319-323. https://doi.org/10.3988/ jcn.2014.10.4.319

Data Sharing Statement

There are no additional data available. All raw data and code are available upon request.

Funding

This research received no funding.

Author Contributions

Whether all authors contributed significantly to the work and approve its publication.

Ethics Declaration

This article does not involve any human or animal subjects, and therefore does not require ethics approval.

Acknowledgements

We would like to express our gratitude to the patients, their families, and all those who have contributed to this study.

Conflicts of Interest

The authors report no conflicts of interest in this work.


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Cite this article

Sagar V. Rati, Varun H.S., Prerana Arun, et al. Unmasking the Mystery: A Case of Atypical Viral Encephalitis Presenting with Unusual Headache and Neurological Deterioration. Ind J Emerg Med. 2026; 12(1): 27-29.


Licence:

Attribution-Non-commercial 4.0 International (CC BY-NC 4.0)

This license enables reusers to distribute, remix, adapt, and build upon the material in any medium or format for noncommercial purposes only, and only so long as attribution is given to the creator.



Received Accepted Published
August 04, 2025 October 06, 2025 March 30, 2026

DOI: https://doi.org/10.21088/ijem.2395.311X.12126.4

Keywords

Viral encephalitis •Atypical headacheCerebrospinal fluid analysisDiagnostic challengesNeurological declineCase reportInfectious disease

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Timeline


Received August 04, 2025
Accepted October 06, 2025
Published March 30, 2026

licence


Attribution-Non-commercial 4.0 International (CC BY-NC 4.0)

This license enables reusers to distribute, remix, adapt, and build upon the material in any medium or format for noncommercial purposes only, and only so long as attribution is given to the creator.



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