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Indian Journal of Maternal-Fetal & Neonatal Medicine

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The Efficacy and Safety of Norethisterone in the Management of Menorrhagia of Dysfunctional Uterine Bleeding

Swati Gett, Senior Resident, Department of Obstetrics and Gynaecology, Kasturba Hospital, Delhi 110006, India. , Swati Gett1 , Shruti Singh2

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Indian Journal of Maternal-Fetal & Neonatal Medicine 5(1):p 63-67, January - June 2018. | DOI: DOI: http://dx.doi.org/10.21088/ijmfnm.2347.999X.5118.11

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Abstract

Introduction: Dysfunctional uterine bleeding (DUB) usually presents as heavy menstrual bleeding without any underlying cause. Norethisterone is the most frequently prescribed drug for dysfunctional uterine bleeding serving 38% of the patient population the reason being cost effectiveness and absence of side effects.

Aim and Objectives: To study the efficacy and safety of Norethisterone in the management of Dysfunctional uterine bleeding.

Material and Methods: A total of50 women between 20 to 50 years of age presenting with abnormal or dysfunctional uterine bleeding during a period of one year included in the study. During each visit a detailed menstrual history was taken and Pictorial Blood Assessment Chart (PBAC) score was calculated. All patients of Dysfunctional uterine bleeding under study treated with Norethisterone and the treatment outcome measured. Results: Among a total of 50 patients, there were 24 (48%) patients belonged to 31-40 years age group with 35.40 years to be a mean of all ages. The mean Haemoglobin level recorded was 7.5gm%. The mean Pictorial Blood Assessment Chat (PBAC) score prior to treatment was 274 which was found to be decreased upto188 after treatment of 3 months with Norethisterone. A total of 32% patients suffered from side effects out of which 20% had nausea as most common.

Conclusions: Norethisterone when used in patients with Dysfunctional uterine bleeding (DUB), it suppresses endometrial development, re-establishes predictable bleeding patterns, decreases menstrual flow and lowers the risk of iron deficiency anaemia.

Keywords: Dysfunctional Uterine Bleeding (DUB); Pictorial Blood Assessment Chart (PBAC).

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DOI: DOI: http://dx.doi.org/10.21088/ijmfnm.2347.999X.5118.11

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