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Study of Hematological Profile and Effect of Antitubercular Medications on the Hematological Derangements in Patients Suffering from Tuberculosis

B. Khandelwal, Professor and HOD, Department of Internal Medicine, Sikkim Manipal University (SMU), Sikkim Manipal Institute of Medical Sciences, Tadong, Sikkim- 737102, Gangtok, India. , Prakash Kumar Koirala , Bidita Khandelwal , Forhad A. Zaman

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Indian Journal of Emergency Medicine 3(1):p 45-50, January - June 2017. | DOI: http://dx.doi.org/10.21088/ijem.2395.311X.3117.7

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Abstract

Tuberculosis (TB) affects large number of people, especially the low socioeconomic status.It continues to intimidate the human race since time immemorial Tuberculosis can cause various haematological abnormalities. The comprehensive study on haematological changes and abnormalities associated with tuberculosis are still lacking. Also there is no systematic documentation about pre-treatment and regular follow up of post-treatment changes in haematological parameters of patients suffering from TB.In this study,an attempt has been made to investigate haematological changes in adult patients suffering from TB and whether deranged haematological parameters in them improves after intensive phase (IP) of antitubercular treatment(ATT).Fifty bacteriologically proven cases of pulmonary and extrapulmonary tuberculosis (EPTB)were studied for various haematological changes at diagnosis and at the end of IP ATT by using automated hematology analyser. At the end of IP ATT, in the RBC series there was statistically significant improvement in the mean haemoglobin ,Packed Cell Volume (PCV), Red cell distribution width (RDW), Mean Corpuscular Volume (MCV), Mean corpuscular Hemoglobin (MCH) and Mean Corpuscular Hemoglobin concentration (MCHC) In the WBC series , mean WBC count and mean granulocyte count in males showed a significant decrease.Rest of the WBC series showed no significant difference in both the groups before and after treatment. In the platelet series, mean platelet volume and mean platelet distribution width showed significant improvement after IP ATT. Thus various haematological changes occur in tuberculosis and these parameters improved after IP ATT without any transfusion of blood products.

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DOI: http://dx.doi.org/10.21088/ijem.2395.311X.3117.7

Keywords

Haematological Changes; Post Treatment; Pre-Treatment; Tuberculosis.  

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