Abstract

The placenta is an abundant source of growth factors. The use of placental extract in plastic surgery as topical wound healing agent earlier itself. The placenta is an abundant source of growth factors, including insulin like growth factors (IGFs), epidermal growth factor (EGF), transforming growth factor beta (TGF-β), and vascular endothelial growth factor (VEGF). This promotes its wide variety of application in various medical conditions.

• 1.   Piyali Datta Chakraborty and Debasish Bhattacharyya, Albert David Ltd, Kolkata, Division of Structural Biology and Bioinformatics, CSIRIndian Institute of Chemical Biology, Kolkata, India, Aqueous Extract of Human Placenta as a Therapeutic Agent.
• 2.   Park SB, Kim KN, Sung E, Lee SY, Shin HC. Human placental extract as a subcutaneous injection is effective in chronic fatigue syndrome: A multi-center, double-blind, randomized, placebocontrolled study. Biological & Pharmaceutical Bulletin. 2016;39:674-679.
• 3.   Erdem E, Yagmur M, Harbiyeli I, Taylan-Sekeroglu H, Ersoz R. Umbilical cord blood serum therapy for the management of persistent corneal epithelial defects. International Journal of Ophthalmology. 2014;7:807-810.
• 4.   Malhotra C, Jain AK. Human amniotic membrane transplantation: Different modalities of its use in ophthalmology. World Journal of Transplantation. 2014;4:111-121.
• 5.   Ohno, H.; Nishimura, N.; Yamada, K.; Shimizu, Y.; Nishimura, R.; Iwase, S.; Sugenoya, J.; Sato, M. Water.
• 6.   Han, J.H.; Kim, M.R.; Park, Y.; Hong, Y.H.; Suh, H.J. Skin permeability of porcine placenta extracts and its physiological activities. Korean J. Food Sci. Anim. Resour. 2013, 33, 356–362. [CrossRef].
• 7.   Hyung-SikSeo, Dong-Jin Lee, Jae-ho Chung, ChangHyun Lee, Ha Rim Kim, Jae Eun Kim, Byung Joo Kim, Myeong Ho Jung, Ki-Tae Ha and Han-Sol Jeong, Hominis Placenta facilitates hair re-growth by upregulating cellular proliferation and expression of fibroblast growth factor-7.
• 8.   Nagae M, Nishio T, Ohnuki K, Shimizu K. Effects of oral administration of equine placental extract supplement on the facial skin of healthy adult women: A randomized, double-blind, placebo-controlled study. Health Sci Rep. 2022.
• 9.   Kaushal V, Verma K, Manocha S, Hooda HS, Das BP. Clinical evaluation of human placental extract (placentrex) in radiation-induced oral mucositis. Int. J. Tissue React. 2001; 23: 105-110.
• 10.   Pal P, Mallick S, Mandal SK, Das M, Dutta AK, Datta PK Bhadra R. Human placental extract: in vivo and in vitro assessments of its melanocyte growth and pigmentinducing activities. Int. J. Dermatol. 2002; 41: 760-767.
• 11.   Pal P, Roy R, Datta PK, Dutta AK, Biswas B, Bhadra R. Hydroalcoholic human placental extract: Skin pigmenting activity and gross chemical composition. Int. J. Dermatol. 1995; 34: 61-66.
• 12.   Hong JW, Lee WJ, Hahn SB, Kim BJ, Lew DH. The effect of human placenta extract in a wound healing model. Ann. Plast. Surg. 2010; 65: 96-100.
• 13.   Shukla, V. K., Rasheed, M. A., Kumar, M., Gupta, S. K. and Pandey, S. S., A trial to determine the role of placental extract in the treatment of chronic nonhealing wounds. J. Wound Care, 2004; 13: 177–179.
• 14.   Chakraborty PD, De D, Bandyopadhyay S, Bhattacharyya D. Human aqueous placental extract as a wound healer. J. Wound Care 2009; 18: 462-467.

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