Abstract

Background: Pathological laughter is a disorder of emotional expression characterized by bouts of uncontrollable laughter with no motivating factor. It is seen in various neurological disorders such as Post Traumatic Brain injury, Post stroke, Multiple sclerosis, Amyotrophic lateral sclerosis, etc. Case Summary: Here, we present a case of a 46 year old male who presented with pathological laughter to the psychiatry outpatient department following acute infarct in the left frontal and right pons area of the brain. Discussion: Our patient had developed pathological laughter subsequently after right pons and left frontal infarct as pseudobulbar affect. Our case report is unique as both the voluntary and involuntary pathways mediating laughter are involved. Conclusion: Hence, our case may be indicative of possible role of combination of antipsychotics and antidepressants, which warrants further research.

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