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RFP Indian Journal of Medical Psychiatry 1(1):p 23-32, January-April 2018. | DOI:
Review Article
Neurological Soft Signs in Schizophrenia
Suprakash Chaudhury , Suprakash Chaudhury1 , Mahesh Hembrom2 , Biswajit L. Jagtap3 , P.S. Murthy4 , Ajay Kumar Bakhla5
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RFP Indian Journal of Medical Psychiatry 1(1):p 23-32, January-April 2018. | DOI:
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Abstract
Neurological Soft Signs (NSS) are postulated to reflect functional disorders in selective areas of the brain. Studies have reported that during the first schizophrenia episode higher total rates of NSS and motor problems are already present. Schizophrenia patients and first degree relatives have more NSS compared to patients with other psychiatric disorders and healthy controls. Whether NSS have a developmental origin or result from some early acquired lesion remains to be decided. Genetic cause of NSS is suggested by studies that indicate that NSS is increased in patients with a positive family history as well as in unaffected first degree relatives of schizophrenia patients. A relationship between NSS and different subtypes of schizophrenia has been observed. Studies indicate that NSS are associated with a more serious clinical course, escalated cognitive dysfunction and unsatisfactory psychosocial outcome has been reported.
Keywords: Neurological Soft Signs; Schizophrenia; Brain Disorder; Genes.
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