Vishnu M. DNB Resident, Department of Emergency Medicine, Apollo International Hospital, Guwahati 781005, Assam, India
Rigen Jyoti Kalita Associate Consultant, Department of Emergency Medicine, Apollo International Hospital, Guwahati 781005, Assam, India
Tandra Biswas Consultant, Department of General Medicine, Apollo International Hospital, Guwahati 781005, Assam, India
Address for correspondence: Vishnu M., DNB Resident, Department of Emergency Medicine, Apollo International Hospital, Guwahati 781005, Assam, India E-mail: vishnudev029@gmail.com
This license enables reusers to distribute, remix, adapt,
and build upon the material in any medium or format for noncommercial purposes
only, and only so long as attribution is given to the creator.
Vishnu M, Kalita RJ, Biswas T. Melioidosis with involvement of CNS: a case report in Northeast India. Ind J Emerg Med. 2025;11(1):59-62.
Timeline
Received : November 15, 2024
Accepted : December 27, 2024
Published : April 20, 2025
Abstract
Melioidosis is a rare and debilitating bacterial infection, continuing to pose a significant threat to public health in endemic regions. Caused by Burkholderia pseudo mallei, which is a widely distributed environmental saprophyte found in stagnant water and soil. This versatile pathogen can manifest in a wide range of clinical presentation often leading to delayed diagnosis and potentially fatal
outcomes. Patient was 41 year old male from urban part of north east India, presented to emergency with complaints of fever, headache, progressive left sided cheek swelling which extends upto left periorbital region associated with confusion. MRI brain showed left temporal lobe abscesses with blood cultures showing growth of Burkholderia pseudomallei. Despite of diagnosis and treatment patient succumbed. This case study emphasizes the importance of early recognition, prompt diagnosis, and appropriate treatment in managing meliodosis with cerebral involvement.
References
1. Wiersinga W.J., Virk H.S., Torres A.G., Currie B.J., Peacock S.J., Dance DAB, Limmathurotsakul D. Melioidosis. Nat Rev Dis Primers. 2018 Feb 1; 4: 17107. doi: 10.1038/ nrdp.2017.107. PMID: 29388572; PMCID: PMC6456913. Limmathurotsakul, D.; Golding, N.; Dance, D.A.; Messina, J.P.; Pigott, D.M.; Moyes, C.L.; Rolim, D.B.; Bertherat, E.; Day, N.P.; Peacock, S.J.; et al. Predicted global distribution of Burkholderia pseudomallei and burden of melioidosis. Nat. Microbiol. 2016.
2. Limmathurotsakul D., Golding N., Dance D.A., Messina J.P., Pigott D.M., Moyes C.L., Rolim D.B., Bertherat E., Day N.P., Peacock S.J., Hay S.I. Predicted global distribution of Burkholderia pseudomallei and burden of melioidosis. Nat Microbiol. 2016 Jan 11; 1: 15008. doi: 10.1038/nmicrobiol.2015.8. PMID: 27571754.
3. Limmathurotsakul D., Peacock S.J. Melioidosis: a clinical overview. Br Med Bull. 2011; 99: 125- 39. doi: 10.1093/bmb/ldr007. Epub 2011 May 9. PMID: 21558159.
4. Datta D., Sekar A., Patnaik A., Mohanty S. A Case-Based Review of Management of CNS Melioidosis. Asian J Neurosurg. 2023 Dec 29; 18(4): 836-838. doi: 10.1055/s-0043-1776736. PMID: 38161600; PMCID: PMC10756835.
5. Lipsitz R., Garges S., Aurigemma R., Baccam P., Blaney D.D., Cheng A.C., Currie B.J., Dance D., Gee J.E., Larsen J., Limmathurotsakul D., Morrow M.G., Norton R, O’Mara E., Peacock S.J., Pesik N., Rogers L.P., Schweizer HP, Steinmetz I., Tan G., Tan P., Wiersinga W.J, Wuthiekanun V., Smith T.L. Workshop on treatment of and postexposure prophylaxis for Burkholderia pseudomallei and B. mallei Infection, 2010. Emerg Infect Dis. 2012 Dec; 18(12): e2. doi: 10.3201/eid1812.120638. PMID: 23171644; PMCID: PMC3557896.
Data Sharing Statement
There are no additional data available.
Funding
This research received no funding.
Author Contributions
All authors contributed significantly to the work and approve its publication.
Acknowledgements
Information not provided.
Conflicts of Interest
The authors report no conflicts of interest in this work.
About this article
Cite this article
Vishnu M, Kalita RJ, Biswas T. Melioidosis with involvement of CNS: a case report in Northeast India. Ind J Emerg Med. 2025;11(1):59-62.
This license enables reusers to distribute, remix, adapt,
and build upon the material in any medium or format for noncommercial purposes
only, and only so long as attribution is given to the creator.
This license enables reusers to distribute, remix, adapt,
and build upon the material in any medium or format for noncommercial purposes
only, and only so long as attribution is given to the creator.