Home > Journals > International Journal of Neurology and Neurosurgery

International Journal of Neurology and Neurosurgery

Submit your article Read this Journals View all journals
Full Text (PDF)
Review Article

Less Neuropathogenesis by HIV-1 C: Co-Operative Action of Viral Factors, Immune and CNS Cells

Mamata Mishra , Mamata Mishra

Author Information

Licence:



International Journal of Neurology and Neurosurgery 8(2):p 47-51, July - December 2016. | DOI: DOI: http://dx.doi.org/10.21088/ijnns.0975.0223.8216.3

How Cite This Article:

Timeline

Received : N/A         Accepted : N/A          Published : N/A

Abstract

  Among 34 million people living with HIV, genetic forms of HIV-1 differ significantly around the globe and sub type C infects highest population worldwide. Although disease severity has been reduced by the successful introduction of cART, complete assessment of therapy to CNS is not potentialy unbeaten. In postHAART era, the predominance of HAND depends upon the likely effect of clade diversity. Neurological complication in HIV infection intimately related to virological, cellular and immunological factors which can either be beneficial or detrimental. Many experts report that immune system cells hinder the healing in subtype B which is somehow suppressed or eliminated in clade C. Other scientists claim that viral factors may mediate the stimulation and secretion of anti-inflammatory cytokines and neuroprotective factorswhich consequences less neuropathogenesis in subtype C infections. Hence less neurocognitive impairment in Indian subtype C is a dispute. This article reviews the co-operative action of viral, cellular and immunological factors involved in HIV-1 associated neurological complications in clade C and elucidate our knowledge in comparison to clade B. 

Keywords: HIV-1 Clade C; Neuropathogenesis; Viral Factors; HAND; Cognitive Impairment. 

References

No records found.


About this article

Cite this article

Licence:



Received Accepted Published
N/A N/A N/A
DOI: DOI: http://dx.doi.org/10.21088/ijnns.0975.0223.8216.3

Keywords


Article Level Metrics

Last Updated

Thursday 30 July 2026, 12:30:22 (IST)

1467

Accesses

5
244
00

Citations


NA
NA
NA

Download citation


Article Keywords

Keyword Highlighting

Highlight selected keywords in the article text.


Timeline

Received N/A
Accepted N/A
Published N/A

licence




Access this article

Reprint Order Form
Buy this Article
Institutional Subscriptions

Share