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Juvenile Granulosa Cell Tumours

Alka B. Patil, Professor and HOD, Department of Obstetrics and Gynecology, ACPM Medical College, Dhule–424001, Maharastra, India. , Alka B. Patil* , Nilay Patel**

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Indian Journal of Trauma and Emergency Pediatrics 9(3):p 185-192, Jul-Sep 2017. | DOI: http://dx.doi.org/10.21088/ijtep.2348.9987.9317.7

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Abstract

Sex cord stromal tumours in adolescence account for less than 3% of ovarian neoplasm in this age group. Juvenile granulosa cell tumour are sex cord stromal tumours occurring in young age group. Clinical presentations of JGCT include precocious puberty, abnormal uterine bleeding, abdominal pain, and abdominal distension. Acute onset of pain may be result of ovarian torsion. Tumour markers for granulosa cell tumour are estradiol, inhibin and anti-mullerian hormone. JGCT are characterized by a prolonged natural history and a tendency to late recurrence. Conservative approach involves unilateral salpingo-oophorectomy with emphasis on fertility preservation. Long-term follow-up is required as JGCTs are associated with late recurrence.

Keywords: Sex Cord Stromal Cells; Juvenile Ganulosa Cell Tumours; Inhibin; Anti-Mullerian Hormone. 

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DOI: http://dx.doi.org/10.21088/ijtep.2348.9987.9317.7

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