Home > Journals > Urology, Nephrology and Andrology International

Urology, Nephrology and Andrology International

Submit your article Read this Journals View all journals
Full Text (PDF)
Original Article

Indications and Long Term Outcomes of Plasmapheresis in Neurological Disorders

Sandeep Sreedharan, Assistant Professor, Department of Nephrology, Amrita Institute of Medical Sciences,Amrita Viswa vidyapeetham, Kochi, Kerala 682041, India. , Vishnu R.S.1 , Sandeep Sreedharan2 , Zachariah Paul Polachirakkal3 , Anil Mathew4 , George Kurian5 , Rajesh Nair6

Author Information

Licence:



Urology, Nephrology and Andrology International 3(1):p 11-14, January- June 2018. | DOI: DOI: http://dx.doi.org/10.21088/unai.2456-5016.3118.2

How Cite This Article:

Timeline

Received : N/A         Accepted : N/A          Published : N/A

Abstract

Background: Plasmapheresis is the treatment of choice in several immune mediated neurological disorders such as Guillain-Barré syndrome and myasthenia gravis. There are only a few studies from India that have looked in to the outcomes and complications related to therapeutic plasmapheresis in neurological disorders. This study was done to examine the indications, complications and outcomes of plasmapheresis in neurological disorders.

Materials & Methods: A retrospective study of patients who underwent plasmapheresis for neurological disorders during last five years was done. Demographic, clinical data, indications, complications related to the procedure, clinical outcome and long term follow up data were collected and analyzed.

Results: Data of sixty patients, who underwent a total of 276 sessions of plasmapheresis were analyzed. Fifty two percent were males and mean age was 45 years. Twenty nine patients (49%) had Acute Inflammatory Demyelinating Polyradiculoneuropathy, 14 (23%) had Myasthenia Gravis and four patients had Acute Disseminated Encephalomyelitis (7%). Other indications were Chronic Inflammatory Demyelinating Polyradiculoneuropathy, transverse myelitis, polymyositis, autoimmune encephalitis, muscular dystrophy, neuromyeltis optica and Febrile infection related epilepsy syndrome. In patients with AIDP, 26 patients (89%) improved. In patients with MG 11 patients (78%) improved. All patients with Autoimmune encephalitis, Polymyositis, Transverse myelitis and Neuromyelitisoptica showed improvement. There was no improvement in patients with Muscular dystrophy and FIRES. Allergic reactions to plasma, intravascular hemolysis and hypotension were the side effects noted which were managed efficiently during procedure. Mild coagulopathy was observed in three patients, but there were no bleeding complications. There were no other significant complications related to procedure. After a mean follow up period of 3 years, 35 patients had complete remission, 10 patients had relapse, 2 patients died whereas 13 patients lost to follow up.

Conclusion: Plasmapheresis is an effective and safe treatment modality in various immune mediated neurological disorders.

Keywords: Plasmapheresis; AIDP; Myasthenia Gravis.

 

References

No records found.


About this article

Cite this article

Licence:



Received Accepted Published
N/A N/A N/A
DOI: DOI: http://dx.doi.org/10.21088/unai.2456-5016.3118.2

Keywords


Article Level Metrics

Last Updated

Sunday 27 September 2026, 13:01:43 (IST)

650

Accesses

6
149
00

Citations


NA
NA
NA

Download citation


Article Keywords

Keyword Highlighting

Highlight selected keywords in the article text.


Timeline

Received N/A
Accepted N/A
Published N/A

licence




Access this article

Reprint Order Form
Buy this Article
Institutional Subscriptions

Share