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International Physiology 8(1):p 27-29, January – April 2020. | DOI: https://dx.doi.org/10.21088/ip.2347.1506.8120.4
Review Article
Glomerular Filtration Barrier and Mechanism of Proteinuria
Amit Kant Singh , Reena Rani Verma1 , Amit Kant Singh2
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International Physiology 8(1):p 27-29, January – April 2020. | DOI: https://dx.doi.org/10.21088/ip.2347.1506.8120.4
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Reena Rani Verma, Amit Kant Singh. / Glomerular Filtration Barrier and Mechanism of Proteinuria. International Physiology.
2020;8(1):27–29.
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Abstract
The first step in urine formation is the filtration of large amounts of fluid
through the glomerular capillaries into Bowman’s capsule. It is around 180 liters per day. Most of this filtrate is reabsorbed leaving only about 1 liter of fluid to be excreted each day. Glomerular capillary wall (GCW) or glomerular filtration barrier (GFB) were coined during 1950. The GCW consists of three distinct but closely interacting layers: the fenestrated endothelium, with its glycocalyx; the podocytes, with their interdigitated foot processes and slit diaphragm; and the intervening glomerular basement membrane (GBM). Proteinuria is associated with kidney disease and cardiovascular mortality. It can be categorised as glomerular, tubular and overflow proteinurea.
Keywords: Glomerular capillary wall (GCW); Glomerular filtration barrier (GFB); Proteinuria.
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Cite this article
Reena Rani Verma, Amit Kant Singh. / Glomerular Filtration Barrier and Mechanism of Proteinuria. International Physiology.
2020;8(1):27–29.
Licence:
| Received | Accepted | Published |
|---|---|---|
| N/A | N/A | N/A |
DOI: https://dx.doi.org/10.21088/ip.2347.1506.8120.4
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