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Indian Journal of Maternal-Fetal & Neonatal Medicine

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Fetal Origin of Adult Disease

Alka Patil, Professor & HOD, Department of Obstetrics and Gynaecology, ACPM Medical College, Dhule– 424001 Maharshtra, India. , Alka Patil1 , Amol Korane2 , Nilay Patel3

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Indian Journal of Maternal-Fetal & Neonatal Medicine 5(1):p 99-117, January - June 2018. | DOI: DOI: http://dx.doi.org/10.21088/ijmfnm.2347.999X.5118.16

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Abstract

The risk of number of chronic diseases in adulthood may have their origins before birth search diseases include non-insulin dependent Diabetes, hypertension and coronary heart disease. Alteration in fetal nutrition and endocrine status may result in adaptations that permanently change the structure physiology and metabolism of the offspring predisposing individuals to metabolic endocrine and cardiovascular diseases in adult life. The developmental origin of adult disease hypothesis is called Barker hypothesis. Under nutrition is programming stimulus when events during critical period of development and change structure and function of the organism. Insulin resistance is early feature of metabolic syndrome and is associated with fetal effects. Adverse events during pregnancy can affect not only the offspring of that pregnancy but also the next generation, women on growth, diet and body composition before and during pregnancy play a major role in programming the future health of her children.

 

Keywords: Fetus; Adult; Barkar; Programming; Thrifty Phenotype; Diabetes. 

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DOI: DOI: http://dx.doi.org/10.21088/ijmfnm.2347.999X.5118.16

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