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Indian Journal of Maternal-Fetal & Neonatal Medicine

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Evaluation of Oral Labetalol Versus Methyldopa in Hypertensive Disorders Complicating Pregnancy

Gauri Dank** , Shubhangi Mande* , Gauri Dank** , Swati Shiradkar*** , Shruti Bhamre****

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Indian Journal of Maternal-Fetal & Neonatal Medicine 3(2):p 87-92, July - December 2016. | DOI: DOI: http://dx.doi.org/10.21088/ijmfnm.2347.999X.3216.5

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Abstract

Aims & Objectives: To compare the efficacy and safety of labetalol versus methyldopa in the management of preeclampsia Materials & Method:s Eligible women were randomly assigned, treated with Tab. Labetalol and Tab Methyldopa alternatively with matching distribution, 85 patients in each group. Results: Labetalol is very effective and has early onset of control of blood pressure control with less side effects. No fetal adverse effects were seen. Conclusion: Labetalol is safe. Inspite of cost, labetalol is very effective and early onset of control of blood pressure is seen. In patients on Labetalol requirement of adding other antihypertensive is much less than methyldopa.With effective control of blood pressure, prevention of eclampsia and the pregnancy can be prolonged to achieve fetal maturity.Labetalol is not associated with adverse fetal effects. 

Keywords: Labetalol; Alpha Methyldopa; Preeclampsia.

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DOI: DOI: http://dx.doi.org/10.21088/ijmfnm.2347.999X.3216.5

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