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International Physiology 1(2):p 51-52, July - December 2013. | DOI:
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Endoplasmic Reticulum Stress and Peripheral Neuropathy: A Relation or a Reaction
Kumar Senthil P. , Kumar Senthil P. , Adhikari Prabha , Jeganathan
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International Physiology 1(2):p 51-52, July - December 2013. | DOI:
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Abstract
The objective of this short communication was to provide evidence for cause-effect inter-relationship and action-reaction association between Endoplasmic reticulum stress (ERS) and Peripheral Neuropathy along a structure-function continuum. ERS layed an important role in pathogenesis of rediabeticand diabetic neuropathy, bortezomib-induced peripheral neuropathy and Familial amyloid polyneuropathy. Whilst the existing evidence confirmed the presence of ERS in peripheral neuropathy, the ERS-based interventions had mixed results.
Keywords: Endoplasmic reticulum stress; Peripheral neuropathy; Neurophysiology; Molecular neurology.
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