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Effectiveness of Homotaurine in the Management of Cognitive Function Disorders Following Traumatic Brain Injury

Gorav Rajput , I D Chaurasia1 , Gorav Rajput2 , Ishant Chaurasia3 , M C Songara4

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International Journal of Neurology and Neurosurgery 12(2):p 89-92, April-June 2020. | DOI: http://dx.doi.org/10.21088/ijnns.0975.0223.12220.4

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I D Chaurasia, Gorav Rajput, Ishant Chaurasia,et al. Effectiveness of Homotaurine in the Management of Cognitive Function Disorders Following Traumatic Brain Injury. Int J Neurol Neurosurg. 2020;12(2):89–92.
 

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Abstract

Introductions:- The traumatic Brain injury (TBI) is an important and large clinical problem worldwide which can lead to severe sequel like cognitive deficits and movement obstacles etc. Cognitive function disorders (CFDS) are group of disorders characterized by one or more of the cognitive domains. CFDs are major Neuro cognitive disorders, which includes three group of disorders1. All these three are characterized by an important cognition (as in memory, language or attention) 2 Overall these functions are of paramount importance and are essential for carrying out day to day activities. Homotaurine is a close structural analogue of the natural amino acid gamma-aminobutyrid acid (GABA) an endogenous neurotransmitter present within the central nervous system. This new compound is used in present study, showing improvement is post TBI cognitive functions related to memory, arousal and aggression. Material and methods:- This study was conducted in the neurosurgery unit of Gandhi Medical College & Associated Hamidia Hospital Bhopal from April 2017 to April 2019, A total number of 76 patients included in the study who had post TBI cognitive functions disturbance. Aim and Objects: To evaluate the effectiveness and safety of Homoturine in the patients suffering from cognitive function disturbance following Traumatic Brain injury. Result:- Homotaurine 100mg TDS for 4 weeks and 50mg TDS for 8 weeks and 50mg BD for
12 weeks appears to be an effective and safe for improving the memory and reducing the irritability and aggression among patients with TBI. Further none of the available treatment option for cognitive disorders affords definitive resolution of symptoms.Conclusion: Our study concludes that the usage of Homotaurine therapy can be safe and useful in traumatic Brain injury in terms of post TBI cognitive and functional outcome with beter recovery though the sympathetic and supporting role of family and friends help in Quick recovery.

Keyword: Cognitive function disorders; Traumatic Brain injury; TBI Homotaurine; Memory; Aggression.
 

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Cite this article

I D Chaurasia, Gorav Rajput, Ishant Chaurasia,et al. Effectiveness of Homotaurine in the Management of Cognitive Function Disorders Following Traumatic Brain Injury. Int J Neurol Neurosurg. 2020;12(2):89–92.
 

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DOI: http://dx.doi.org/10.21088/ijnns.0975.0223.12220.4

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