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Effect of Tocotrienol Rich Fraction Supplementation [TRF] on Lipid Profiles in Healthy Individuls

Brijendra Pratap Mishra , B.P. Mishra* , Sajjanlal Verma** , M.L. Kanojia*** , Z.G. Badade****

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Journal of Cardiovascular Medicine and Surgery 3(1):p 13-18, Jan-June 2017. | DOI: http://dx.doi.org/10.21088/jcms.2454.7123.3117.2

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Abstract

 Tocotrienols are member of the vitamin E family, recommended as supplements for maintaining optimum health. Tocotrienols have multieffects as antiangiogenic, antiinflammatory, antidyslipidemic, proapoptotic, antiproliferative, free radical scavenger,radiation countermeasures. The main objective of this study was to determine the effects of TRF supplementation on lipid profile in healthy individuals at low dose of 160 mg/day for 6 months. Method: One hundred subjects were recruited from two age groups, 35-50 years (n=50) and above 50 years age (n=50) and randomly assigned to receive either TRF supplement or placebo capsules for six months. Blood samples investigated at 0, 3 and 6 months. Result: There were no significant alterations observed in total cholesterol, LDL, triglycerides while significant changes had been observed in HDL cholesterol, particularly 6 month TRF supplemented individuals (Pï‚£0.01). Conclusion: Our result indicate that daily supplementation of TRF up to 6 months, raised plasma HDL cholesterol levels, reflects the antiatherogenic properties, predicts for the prevention of cardiovascular diseases risks.
Further need of research study on lipid profile & other cardiac markers with different dose and duration of TRF is indispensable in cardiovascular and other diseases.

 

 

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DOI: http://dx.doi.org/10.21088/jcms.2454.7123.3117.2

Keywords

TRF; Lipid Profiles; Free Redical; Cardiovascular Diseases.

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