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Effect of Intravenous Dexmedetomidine for Intranasal Surgeries under General Anesthesia

R. Murali , R Gowthaman , R Murali

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Indian Journal of Anesthesia and Analgesia 6(6):p 2234-2240, November-December 2019. | DOI: http://dx.doi.org/10.21088/ijaa.2349.8471.6619.56

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R Gowthaman, R Murali. Effect of Intravenous Dexmedetomidine for Intranasal Surgeries under General Anesthesia. Indian J Anesth Analg. 2019;6(6 Part - II):2234-2240.

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Received : N/A         Accepted : N/A          Published : N/A

Abstract

Background and Objectives: Controlled hypotension has been used to reduce bleeding and to optimize visualization of surgical field during intranasal surgeries. Dexmedetomidine, an alpha-2 agonist can be an effective agent to provide controlled hypotension and it also provides sedation and analgesia with minimal side effects. The present study was undertaken to evaluate the effect of intravenous dexmedetomidine for intranasal surgeries under general anesthesia. Materials and Methods: Sixty patients aged 20 to 60 years, belonging to ASA I & II and undergoing elective intranasal surgeries under general anesthesia were included in the study. Patients were randomly allocated to two Groups (30 each), Group D and Group P. Patients in Group D received intravenous dexmedetomidine 1 mcg/kg in 10 ml of normal saline and Group P received placebo. Data obtained were subjected to analysis using statistical software SPSS vs 24. Results: Bleeding score was significantly lower in Group D (86.7% with bleeding Score 1) vs in Group P (46.7% with bleeding Score 3 and 40% with a Score 2) with a p value < 0.001. The Mean arterial pressure was significantly lower in Group D than Group P throughout the surgery with p value 0.035. The Heart rate was also lower throughout surgery in Group D than Group P significant with p value < 0.001. Conclusion: Intravenous dexmedetomidine for intranasal surgeries under general anesthesia reduces bleeding at surgical site and provides better visibility of operative field and helps achieve controlled hypotension with minimal side effects.

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Cite this article

R Gowthaman, R Murali. Effect of Intravenous Dexmedetomidine for Intranasal Surgeries under General Anesthesia. Indian J Anesth Analg. 2019;6(6 Part - II):2234-2240.

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DOI: http://dx.doi.org/10.21088/ijaa.2349.8471.6619.56

Keywords

Dexmedetomidine; Controlled hypotension; Placebo; Bleeding score.

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