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Does the Duration of DM & HbA1c Levels Influence the Onset of Diastolic Dysfunction?

Melvin George, Assistant Professor, Dept. of Clinical Pharmacology, SRM Medical College Hospital & Research Centre, Kattankulathur, Chennai, Tamil Nadu 603203, India. , S. Prasanna* , Amrita Jena** , Dhandapani V.E.*** , Melvin George****

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Journal of Cardiovascular Medicine and Surgery 3(2):p 126-131, Jul-Dec 2017. | DOI: http://dx.doi.org/10.21088/jcms.2454.7123.3217.8

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Abstract

Diabetes Mellitus is a serious, chronic disease which is characterized by insufficient production of insulin by the pancreas. Myocardial infarction, stroke, nephropathy, peripheral vascular disease, retinopathy, peripheral & autonomic neuropathy resulting in premature death are some of the serious complications associated with diabetes mellitus. Evidence gathered from earlier data shows that there is a high prevalence of diastolic dysfunction among subjects with DM than in nondiabetic patients, even without clinical evidence of coronary artery disease. The objective of our study was to observe the prevalence of diastolic dysfunction in asymptomatic type 2 diabetes mellitus patients. We included 100 subjects with a diagnosis of type 2 DM and 100 age and gender matched controls. Diastolic function was assessed using transthoracic echocardiography. Our study showed that the risk of diastolic dysfunction was significantly higher among the patients with longer duration of DM. Similarly patients with higher HbA1c were more likely to suffer from diastolic dysfunction than patients with lower HbA1c levels. Early detection of diastolic dysfunction in diabetic subjects is warranted to prevent left ventricular dysfunction.

 

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DOI: http://dx.doi.org/10.21088/jcms.2454.7123.3217.8

Keywords

Diabetes; Diastolic Dysfunction; Echocardiography; Left Ventricular Dysfunction; HbA1c. 

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