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Case Report

Congenital Multiple Antithrombotic Factors Deficiency in Neonate: A Rare Case Report

Thahseen Nilofar S , Ahamed Ashar Ali H1 , Thahseen Nilofar S2

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Indian Journal of Trauma and Emergency Pediatrics 12(2):p 17-19, April-June 2020. | DOI: http://dx.doi.org/10.21088/ijtep.2348.9987.12220.3

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Ahamed Ashar Ali H, Thahseen Nilofar S. Congenital Multiple Antithrombotic Factors Deficiency in Neonate: A Rare Case Report. Indian J Trauma Emerg Pediatr. 2020;12(2):17–19.
 

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Abstract

Background: Protein C, Protein S and Antithrombin III are negative regulators of coagulation. Homozygous protein C deficiency is a rare inherited disorder manifesting as neonatal purpura fulminans. A two week old female baby delivered at term, developed purpuric lesions over the left thigh and progressing to other areas. Investigations showed
negligible protein C level, besides meagre protein S and antithrombin III levels. The diagnosis of inherited combined protein C, protein S and antithrombin III deficiency was made. Conclusion: Genetic analysis will help in prenatal diagnosis in future pregnancies.

Keywords: Antithrombin III; Purpura fulminans; Thrombophilia.
 

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Cite this article

Ahamed Ashar Ali H, Thahseen Nilofar S. Congenital Multiple Antithrombotic Factors Deficiency in Neonate: A Rare Case Report. Indian J Trauma Emerg Pediatr. 2020;12(2):17–19.
 

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DOI: http://dx.doi.org/10.21088/ijtep.2348.9987.12220.3

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