Home > Journals > Indian Journal of Anesthesia and Analgesia

Indian Journal of Anesthesia and Analgesia

Submit your article Read this Journals View all journals
Full Text (PDF)
Original Article

Comparison of Intrathecal Fentanyl and Midazolam as an Adjuvants to Hyperbaric Bupivacaine in Parturients undergoing Elective Cesarean Sections

Arpita Jaiswal, Associate Professor, Dept. of Obstetrics and gynecology, Jawaharlal Nehru Medical College, Sawangi (Meghe), Wardha, Maharashtra, 442005, India. , Amol Singam1 , Arpita Jaiswal2 , Rashmi Deshpande3 , Nandkishor Agrawal4 , Roona Singh5

Author Information

Licence:



Indian Journal of Anesthesia and Analgesia 4(4):p 1128-1133, October-December 2017. | DOI: http://dx.doi.org/10.21088/ijaa.2349.8471.4417.34

How Cite This Article:

Timeline

Received : N/A         Accepted : N/A          Published : N/A

Abstract

Aims: The aim of this study was to evaluate and compare the efficacy and safety of fentanyl and midazolam given intrathecally with hyperbaric 0.5% bupivacaine in patients undergoing elective caesarean sections. Materials and Methods: A total of 180 women undergoing elective cesarean section were included in a prospective, double-blind, controlled trial. Patients were divided in three groups of 60 each and randomly assigned to receive spinal anesthesia with 2 mL 0.5% hyperbaric bupivacaine with 0.4ml of normal saline ( Group C) , 2 mL 0.5% hyperbaric bupivacaine with 12.5 g fentanyl (Group F) and 2 mL 0.5% hyperbaric bupivacaine with 2mg midazolam (Group M). Each group had a total volume of 2.4ml made by addition of normal saline. Onset and duration of sensory and motor block, duration of postoperative analgesia, hemodynamic effects and adverse effects due to study drugs were recorded and Statistical analysis was done. Results: Duration of analgesia was significantly prolonged in fentanyl group (254.83±14.84 mins.) compared to midazolam group(211.16±15.02 mins) and bupivacaine group (143.16±13.08 mins.) Hemodynamic parameters were comparable in the three groups. Side effects in all three groups were minimal. Apgar score did not differ in 3 groups. Conclusion: 12.5 g fentanyl seems to be a better alternative to 2 mg midazolam as an adjuvant to bupivacaine in patients undergoing elective cesarean section as it prolongs the duration of analgesia without any deleterious effects on the mother and baby.

References

No records found.


About this article

Cite this article

Licence:



Received Accepted Published
N/A N/A N/A
DOI: http://dx.doi.org/10.21088/ijaa.2349.8471.4417.34

Keywords

Fentanyl; Midazolam; Cesarean Section; Spinal Anesthesia. 

Article Level Metrics

Last Updated

Saturday 07 February 2026, 21:07:49 (IST)

1189

Accesses

0
194
00

Citations


NA
NA
NA

Download citation


Article Keywords

Keyword Highlighting

Highlight selected keywords in the article text.


Timeline

Received N/A
Accepted N/A
Published N/A

licence




Access this article

Reprint Order Form
Buy this Article
Institutional Subscriptions

Share