Journal Home
Browse Journal
Journal Info
Submit
Stay Connected

Indian Journal of Pathology: Research and Practice

Track Submission | Help | Blog | Career

Explore Content
Journals Books Special Supplement Souvenir
Author Guidelines
Journal Book Chapter Special Supplement
Events
Order Online
About Us

SUBMIT

Home > Journals > Indian Journal of Pathology: Research and Practice

Indian Journal of Pathology: Research and Practice

Submit your article Read this Journals View all journals

Journal Home
Browse Journal
Journal Info
Submit
Stay Connected

Heading

Description: R1 MRI showed a hypodense, non-enhancing left frontal lesion with ill-defined margins and mild mass effect. Histomorphology (Fig. 1A–1B) showed increased cellularity with mild atypia of tumor cells in a dense fibrillary background (H&E10X & Inset 40X). IHC showed IDH mutation (Fig. 1C, 40X), ATRX loss (Fig. 1D,40X), p53 positivity (~10%) (Fig. 1E,10X), and a low Ki-67 index. (<5%) (Fig. 1F, 10X) in tumor cells.

Heading

Description: 2A: T2/FLAIR MRI shows a hyperintense lesion in the right frontoparietal white matter with irregular margins and perilesional edema, causing mild compression of adjacent sulci and ventricles, Histopathology reveals increased cellularity with nuclear atypia and mitotic activity (Fig. 2B, H&E, 40X), Tumor cells show IDH mutation (Fig. 2C, IHC, 40X) and diffuse cytoplasmic GFAP positivity (IHC, 40X) (Fig. 2D)

Heading

Description: Fig. R3 MRI showed a heterogeneously enhancing fronto-parietal mass with central necrosis, vasogenic edema, and midline shift. Histomorphology (Fig. 3A–3C) showed diffusely infiltrating atypical cells with geographic necrosis, increased cellularity, microvascular proliferation, marked atypia, & mitoses. IHC showed IDH mutation (Fig. 3D), ATRX loss (Fig. 3E), p53 positivity in 30–40% of tumor cells (Fig. 3F) and diffuse GFAP positivity (Fig. 3G).

Heading

Description: Fig. R4 MRI showed an ill-defined right frontal intra-axial mass with T2/FLAIR hyperintensity, cystic areas, vasogenic edema, and mild midline shift; histomorphology (Fig. 4A&B, H&E,10X) showed diffuse round cells with perinuclear halos and brisk mitoses (40X). IHC showed IDH-mutation (Fig. 4C, 40X), ATRX-retained (Fig. 4D, 40X), p53-negative (Fig. 4E, 10X), Ki-67 (30–40%, 10X) (Fig. 4F, 10X), and GFAP positivity (Fig. 4G, 40X) in tumor cells

Heading

Description: Figure R5 MRI showed an aggressive right frontoparietal mass with central necrosis, extensive edema, and marked midline shift; histology (Fig. 5A–5C) shows palisading necrosis, atypia, and microvascular proliferation. IHC shows IDH-wild type (Fig. 5D, 10X) and ATRX retained (Fig. 5E, 40X).

Heading

Description: Figure 6A (H&E, 40X) showed moderate cellularity with piloid cells and Rosenthal fibers; Fig. 6B showed Ki-67 <2% (40X); Fig. 7A MRI showed a well-circumscribed cystic parietal lesion with an enhancing mural nodule. Fig. 7B, (H&E, 10X) showed peripheral invasion with pleomorphic cells with (Fig. 7C H&E, 40X) spindle/epithelioid cells, multinucleated astrocytes, and xanthomatous changes with BRAF V600E positivity (Fig. 7D IHC-40X) & rich reticulin network (Fig. 7E, 40X)

Heading

Description: Fig. 8A MRI showed a large heterogeneous temporal solid-cystic mass with mass effect; Fig. 8B showed neuronal component (ganglion cells) within the tumor area (H&E, 40X). Fig. 8C showed glial component of tumor with eosinophilic granular bodies (H&E, 40X), and dystrophic calcification in ganglion cells (Fig 8D, H&E, 40X), IHC showed GFAP positivity in glial component (Fig 8E, IHC-40X) & synaptophysin positivity in neoplastic ganglion cells (Fig. 8F, IHC-40X)

Heading

Description: Fig. 9A Section shows uniform round cells, thickened and hyalinized blood vessels and psammomatous calcification (H&E, 10X) some cells showed perinuclear clearing and intratoumoral hemorrhage. (Fig. 9B Inset H&E, 40X). Fig. 9C showed GFAP-positive reactive astrocytes (IHC, 40X) and synaptophysin-positive tumor cells (Fig. 9D, IHC 10X)

Heading

Description: Fig. 10A MRI showed a well-defined lobulated parietal lobe lesion, heterogeneously T2-hyperintense with cystic areas, septations, mild edema, heterogeneous enhancement, and mass effect. Fig. 10B Histopathology showed pseudorosettes, true rosettes, with round-to-oval tumor nuclei (H&E, 40X) with Perinuclear dot/ ring-like EMA positivity (Fig. 10C, IHC-40X), GFAP shows perivascular accentuation (Fig. 10D, IHC-40X), and the Ki-67 index >20% (Fig. 10E, IHC-40X) in tumor cells

Heading

Description: Figure 11A Section shows papillary pattern composed of fibrovascular fronds (H&E, 10X) with single layer of cuboidal to columnar epithelial cells & round/ oval nuclei. (Fig 11B H&E, 40X) with GFAP positivity in reactive astrocytes or entrapped glial tissue. (Fig 11C, IHC-10X).

Heading

Description: Fig. 13A MRIshowed a hyperdense midline posterior fossa mass arising from the cerebellar vermis, compressing the 4th ventricle and causing obstructive hydrocephalus, with surrounding edema and heterogeneoenhancement; Fig. 13B showed small round blue cells with hyperchromatic nuclei and a high N:C ratio andHomer Wright rosettes with focal synaptophysin positivity (Fig. 13C).

Heading

Description: Figure 14A showed pale nodular areas with neuronal differentiation surrounded by densely packed hyperchromatic cells with reticulin-positive internodular regions (Fig. 14B, IHC-10X), NSE +ve pale nodules (Fig. 14C, IHC-10X) and synaptophysin-positive nodules and negative internodular areas (Fig. 14D, IHC-10X)

Heading

Description: Fig. 15A showed sheets of poorly differentiated cells infiltrating adjacent CNS tissue (H&E, 4X). The tumor showed embryonal cells with a high N:C ratio and Homer Wright rosettes (Fig. 15 B&C; H&E, 10X, 40X), IHC showed synaptophysin positivity (Fig. 15D), and Ki-67 index > 50% (Fig. 15E)

Heading

Description: Fig. 16A showed a highly cellular smallround cell tumor with a high N:C ratio and rosettes (H&E, 10X). Tumor cells were chromogranin-positive (Fig.16B, 10X), S100 positivity (Fig. 16C) and Ki-67 index of ~35% (Fig. 16D)

Heading

Description: Figure 17A showed Antoni A areas with Verocay bodies in adjacent Antoni B area (H&E, 10X). Tumor cells- S100 positive (Fig. 17B; IHC, 40X). Figure 18 A&B showed bland spindle cells with thin, wavy nuclei in a loose myxoid stroma with collagen (H&E, 10X, 40X)