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Bench Evidence for Diabetic Peripheral Neuropathy: What does Animal Studies Inform Clinical Practice?

Kumar Senthil P. , Kumar Senthil P. , Adhikari Prabha , Jeganathan

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Journal of Animal Feed Science and Technology 2(1):p 42-43, January - June 2014. | DOI:

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Abstract

This short communication was aimed at enumerating the evidence from animal models of Diabetic peripheral neuropathy (DPN) in order to imply clinical decision-making in routine practice through a preliminary search of PubMed. The animal models demonstrated abnormalities in motor nerve conduction velocity (MNCV) and hind- imb digital sensory nerve conduction velocity (SNCV) deficits, thermal hypoalgesia, tactile allodynia, and a remarkable loss of intraepidermal nerve fibers. The streptozotocin (STZ)-induced diabetic rat is the most commonly employed animal model used to study mechanisms of painful diabetic neuropathy through behavioral assays of mechanical allodynia and heat hyperalgesia and to evaluate potential therapies.

Keywords: Bench-to-bedside; Knowledge translation; Evidence-based practice; Animal sciences. 

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