Home > Journals > Indian Journal of Emergency Medicine

Indian Journal of Emergency Medicine

Submit your article Read this Journals View all journals
Full Text (PDF)
Original Article

Assessment of Short-term Electrocardiographic Changes Induced by Antibiotic Amoxicillin and Clavulanate

Shambhulinga Purad , Shambhulinga Purad1 , Jagadish Shisol2

Author Information

Licence:



Indian Journal of Emergency Medicine 5(4):p 233-238, October-December 2019. | DOI: DOI: http://dx.doi.org/10.21088/ijem.2395.311X.5419.3

How Cite This Article:

Shambhulinga Purad, Jagadish Shisol. Assessment of Short-term Electrocardiographic Changes Induced by Antibiotic Amoxicillin and Clavulanate. Indian J Emerg Med. 2019;5(4):233–238

Timeline

Received : N/A         Accepted : N/A          Published : N/A

Abstract

Background and Objectives: Antibiotics are widely used for variety of infections. Drugs like Macrolides, Flouroquinolones can cause prolongation of the QT interval. The objective of this study was to assess the changes in 12 lead Electrocardiogram of patients receiving intravenous Amoxicillin and Clavulanate, parameters like heart rate and corrected QT interval (QTc) were analyzed. Methods: A total of 40 patients who received intravenous Amoxicillin and Clavulanate were enrolled in the study. Serial 12 lead surface Electrocardiogram were taken at 4 time points as follows. First ECG taken before the administration of the antibiotic. These were followed by a 10 minutes, 20 minutes and 60 minutes of infusion. The parameters of Electrocardiogram viz; Heart rate, QTc Interval were assessed. Results: In our study we found that there was mean increase in the heart rate of less than 2 beats per minute and mean increase in QTc interval of 9.6 ms at 60 minutes when compared to baseline. This difference was statistically signi cant but clinically not signi cant as the corrected QT interval was still within the normal range. Conclusion: Administration of antibiotics like Amoxicillin and Clavulanate, through intravenous route caused a minimal though statistically signi cant increase in heart rate and QTc at 60 minutes compared to baseline, in patients without cardiovascular disease or electrolyte disturbances. However the corrected QT intervals remained in the normal range. These results point to the need for further studies in larger groups of patients including those with cardiovascular disease and other comorbidities.

Keywords: Antibiotic; Amoxicillin and clavulanate; ECG; Heart rate; QTc.

References

No records found.


About this article

Cite this article

Shambhulinga Purad, Jagadish Shisol. Assessment of Short-term Electrocardiographic Changes Induced by Antibiotic Amoxicillin and Clavulanate. Indian J Emerg Med. 2019;5(4):233–238

Licence:



Received Accepted Published
N/A N/A N/A
DOI: DOI: http://dx.doi.org/10.21088/ijem.2395.311X.5419.3

Keywords


Article Level Metrics

Last Updated

Tuesday 07 July 2026, 11:38:31 (IST)

2530

Accesses

4
890
00

Citations


NA
NA
NA

Download citation


Article Keywords

Keyword Highlighting

Highlight selected keywords in the article text.


Timeline

Received N/A
Accepted N/A
Published N/A

licence




Access this article

Reprint Order Form
Buy this Article
Institutional Subscriptions

Share