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Antimicrobial susceptibility patterns and risk factors profile of patients with septicaemic meliodosis: Single centre experience over a period of five years

Saurabh Sharma Assistant Professor, Department of Orthopaedics, Gandhi Medical College, Bhopal, Madhya Pradesh 462001, India. , Archa Sharma1 , Pragya Ranjana2 , Saurabh Sharma3 , Neha Sharma4 , Kamal Sharma5

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Journal of Microbiology and Related Research 4(1):p 17-20, Jan-June 2018. | DOI: DOI: http://dx.doi.org/10.21088/jmrr.2395.6623.4118.3

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Abstract

Aims and Objective: In this paper, we review the antimicrobial susceptibility patterns and risk factors in patients with septicaemic meliodosis, seen over a period of five years - from 2010 to 2014.

Material and methods: We have collected all blood culture of B. pseudomallei positive patients, between the periods January 2010 to December 2014 for the study. Identification of B. pseudomalleifrom positive blood cultures was done by cultural characteristics where all isolates were serologically confirmed using polyclonal antiserum raised in rabbits. Antimicrobial susceptibility testing was done using standardized protocols. Geometric mean MIC for each antibiotic for each year was calculated and reported.

Results: A total of 54 patients were found to have B. pseudomallei septicaemia during the study period, 8 in 2010, 14 in 2011, 14 in 2012, 11 in 2013 and 7 in 2014. Of them, 47 (87%) were males, while the rest 7 (13%) were females. Ages of the patients ranged from 0 to 67 years (mean - 43.22±14.778).The organism was largely susceptible to ceftazidime, doxycycline, trimethoprimsulfamethoxazole and carbapenems. We found only a single isolate of B. pseudomallei which showed resistance to meropenem and doxycycline.

Conclusion: The study results re-assured that the organism is largely susceptible to routinely used antibiotics. The collation of MIC data over 5 years in the tertiary care institution was unable to reveal an evident MIC trend for ceftazidime, doxycycline, trimethoprim-sulfamethoxazole and carbapenems.

Keywords: Septicaemic Meliodosis; B. Pseudomallei; Antibiotic Sensitivity; Risk Factors. 

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DOI: DOI: http://dx.doi.org/10.21088/jmrr.2395.6623.4118.3

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