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Aflatoxicosis; Diagnosis and Treatment in Livestock

Deep Narayan Singh, Mamta null, Ajay Kumar, Rajneesh Sirohi

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Journal of Animal Feed Science and Technology 11(1):p 27-34, January-June 2023. | DOI: https://doi.org/10.21088/jafst.2321.1628.11123.3

How Cite This Article:

Deep Narayan Singh, Mamta, Ajay Kumar et al./Aflatoxicosis; Diagnosis and Treatment in Livestock /Journal of Animal Feed Science and Technology 2023;11(1):27-34.

Timeline

Received : April 12, 2023         Accepted : April 29, 2023          Published : June 30, 2023

Abstract

Aflatoxicosis is a fungal borne toxicosis that may affect almost all species of livestock in India as well as abroad. Aflatoxins are major class of mycotoxins produced primarily by Aspergillus flavus i.e. most common grain mold fungi. The fungus grows on carbohydrate rich feeds such as peanuts, cottonseed, corn, sorghum and cereal grains when they are stored in hot conditions without adequate drying and aeration. Aflatoxin M1 found in milk of dairy cattle is the metabolite of Aflatoxin B1 that occurs in feed materials. Aflatoxicosis is a problem in livestock, most notably swine and cattle. Gross lesions include hepatic enlargement, congestion, yellow discoloration, and friability; petechiae or more generalized hemorrhage; and edema and ecchymotic or petechial hemorrhages of the gall bladder. Cattle are more resistant than pigs, but the typical lesions of aflatoxicosis, as described above, can be found following exposure. Fibrosis and bile duct proliferation may be extensive and found together with fibrotic veno-occlusion of the central veins. Sheep are resistant to aflatoxin.


References

  • 1.   Abarca M.L., Bragulat M.R., Castella G. And Cabanes f. J.: Mycoflora and aflatoxin-producing strains in animal mixed feeds. J. Food Protect., 1994, 57, 256-258.
  • 2.   Anonymous.: The regulations of Turkish food codex (Turkish). The Official J., 1997, 23172: 124.
  • 3.   Bastianello S.S., Nesbit J.W., Williams M.C. and Lang A.L.: Pathological finding in a natural outbreak of aflatoxicosis in dogs. Onderstepoort J. Vet. Res., 1987, 54, 635-640.
  • 4.   Cheeke, P. R., and L. R. Shull. 1985. Natural Toxicants in Feeds and Poisonous plants. pp 393476. Corn shipped in interstate commerce for use in animal feeds; action levels for aflatoxin in animal feeds. Fed. Reg. 54:100, 22622.
  • 5.   Cook W.O., Richard J.L., Osweiler G.D. and Trampel D.W. : Clinical and pathological changes in acute bovine aflatoxicosis : rumen motility and tissue and fluid concentrations of aflatoxins B1 and M1. Amer. J. Vet. Res., 1986, 47, 1817-1825.
  • 6.   Coulombe J.A.R.: Biological action of mycotoxins. J.Dairy Sci., 1993, 76, 880-891.
  • 7.   Dalcero A., MagnolI C., Chiacchiera S., Palacios G.and Reynoso M.: mycoflora and incidence of aflatoxin B1, zearalenonev and deoxynivalenol in poultry feeds in Argentina. Mycopathologia, 1997, 137, 179-184.
  • 8.   Fink-Gremmels J.: Mycotoxins: Their implications for human and animal health. Vet. Quart., 1999, 21, 115-120.
  • 9.   Goldblat, L. A., L. F. Kubena, and T. D. Phillips. 1989. Prevention of aflatoxicosis by addition of hydrated sodium, calcium, aluminosilicate to the diets of growing barrows. Am. J. Vet. Res. 50:416.
  • 10.   Henry C.W. Feed quality control for optimum bird performance. World Poultry, 1996, 12 (10), 65-67.
  • 11.   Hertrampf J.W.: The mycotoxin hazard can be easily solved. World Poultry, 1994, 10 (8), 55-57.
  • 12.   Hinton M.H.: Infections and intoxications associated with animal feed and forage which may present a hazard to human health. Vet. J., 2000, 159, 124-138.
  • 13.   Lillehoj, E. B., T. E. Cleveland, and D. Bhatnagar. 1991. Mycotoxins in feedstuffs: Production in novel substrates. pp 399-413.
  • 14.   Mahmoud A.L.E. : Toxigenic fungi and mycotoxin content in poultry feedstuff ingredients. J. Basic Microbiol., 1993, 33, 101-104.
  • 15.   Newberne J.W., Bailey W.S. and Seibold H.R.: Notes on a recent outbreak and experimental reproduction of hepatitis X in dogs. J Am. Vet. Med. Assoc., 1955, 127, 59-62.
  • 16.   Newberne P.M., Russo R. and Wogan G.N. : Acute toxicity of aflatoxin B1 in dog. Pathologia Veterinaira, 1966, 3, 331-340.
  • 17.   Nilipour A.H. : Keeping insects and mycotoxins out of silos. World Poultry, 1996, 12 (9), 24-25.
  • 18.   Park D.L., Controlling aflatoxin in food and feed. Food Technol., 1993, 47, 92-96.
  • 19.   Park FL., D. L., L. S. Lee, R. L. Price, and A. E. Pohland. 1988. Review of the decontamination of aflatoxins by ammoniation: Cur-rent status and regulation. J. Assoc. Off. Anal. Chem. 71:685.
  • 20.   Pier, A. C. 1981. Mycotoxins and animal health. In: Advances in Veterinary Science and Comparative Medicine. Vol. 25. pp185-243. Academic Press, New York.
  • 21.   Pier, A. C.(1986). Immunomodulation in aflatoxicosis. In: J. L.Richard and J. T. Thurston (Ed.) Diagnosis of Mycotoxicoses. pp 143-148. Martinus Nijhoff, Boston, MA.
  • 22.   Pier, A. C. 1987. Aflatoxicosis and immunosuppression in mam-malian animals. I n M. S. Zuber, E. B. Lillehoj, and B. L. Renfro (Ed.) Aflatoxin in Maize. pp 58435. CIMMYT, Mexico.
  • 23.   Pier, A. C. 1991. The influence of mycotoxins on the immune system. I n J. E. Smith and R. S. Henderson (Ed.) Mycotox-ins and Animal Foods. pp 489-497. CRC Press, Boca Raton,FL.
  • 24.   Pier, A. C., and M. E. McLoughlin. 1985. Mycotoxin suppression of immunity. In: J. Lacey (Ed.) Trichothecenes and Other Mycotoxins. pp 507-519. John Wiley and Sons, New York.
  • 25.   Pier, A. C., E. L. Belden, J. A. Ellis, E. B. Nelson, and L. R. Maki. 1989. Effects of cyclopiazonic acid and aflatoxin singly ands effects of aflatoxins on animals 3967 in combination on selected clinical, pathological and im-munological responses of guinea pigs. Mycopathologia 105:135.
  • 26.   Pier, A. C., M. E. McLoughlin, J. L. Richard, A. L. Baetz, and R.R. Dahlgren. 1985. In utero transfer of aflatoxin and selected effects on neonatal pigs. In: J. Lacey (Ed.) Trichothecenes and Other Mycotoxins. pp 495-506. JohnWiley and Sons, New York.
  • 27.   Pier, A. C., M. J. Varman, R. R. Dahlgren, E. L. Belden, and L. R. Maki. 1986. Aflatoxic suppression of cell mediated immune response and interaction with T-2 toxin. In: P. S. Steyn and R. Vleggar (Ed.) Mycotoxins and Phycotoxins. pp 423-434. Elsvier, Amsterdam.
  • 28.   Purwoko H.M., Hald B. and Wolstrup J.: Aflatoxin content and number of fungi in poultry feedstuffs from Indonesia. Lett. Appl.Microbiol., 1991, 12, 212- 215. review. Anim. Res., 2002, 51, 81-99.
  • 29.   Rustom I.Y.S. : Aflatoxin in food and feed : occurrence, legislation and inactivation by physical methods. Food Chem., 1997, 59, 57-67.
  • 30.   Skrinjar M., Stubblefield R.D., Vujicic I.F. and Stojanovic E. : Distribution of aflatoxin producing moulds and aflatoxins in dairy cattle feed and raw milk. Acta Microbiol. Hung., 1992, 39, 175-179.
  • 31.   Tapia M.O. and Seawright A.A.: Experimental combined aflatoxin B1 and ochratoxin A intoxication in pigs. Aust. Vet. J., 1985, 62, 33-37.

Data Sharing Statement

There are no additional data available. All raw data and code are available upon request.

Funding

This research received no funding.

Author Contributions

All authors contributed significantly to the work and approve its publication.

Ethics Declaration

This article does not involve any human or animal subjects, and therefore does not require ethics approval.

Conflicts of Interest

No conflicts of interest in this work.


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Cite this article

Deep Narayan Singh, Mamta, Ajay Kumar et al./Aflatoxicosis; Diagnosis and Treatment in Livestock /Journal of Animal Feed Science and Technology 2023;11(1):27-34.


Licence:

Attribution-Non-commercial 4.0 International (CC BY-NC 4.0)

This license enables reusers to distribute, remix, adapt, and build upon the material in any medium or format for noncommercial purposes only, and only so long as attribution is given to the creator.


Received Accepted Published
April 12, 2023 April 29, 2023 June 30, 2023

DOI: https://doi.org/10.21088/jafst.2321.1628.11123.3

Keywords

AflatoxinCornFungusFDA

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Received April 12, 2023
Accepted April 29, 2023
Published June 30, 2023

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Attribution-Non-commercial 4.0 International (CC BY-NC 4.0)

This license enables reusers to distribute, remix, adapt, and build upon the material in any medium or format for noncommercial purposes only, and only so long as attribution is given to the creator.


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