Journal of Dermatology

Norepinephrine (NE) is commonly recommended as a first-line vasopressor treatment for the majority of adult patients with acute circulatory failure. Critically ill patients with circulatory shock may need rescue treatment with high doses of NE, which can be associated with a poor outcome due to excessive vasoconstriction. Herein we present a patient of post partum hypovolemic shock who developed gangrenous changes in the digits of her hands after norepinephrine administration.

Drug administration with transdermal patches is a non-invasive technique. It is an adhesive patch that is intended to penetrate the skin and enter the bloodstream, distributing a precise dosage of medication throughout the body. Compared to other administration methods, transdermal medication delivery is less intrusive, more patient-friendly, and able to avoid first-pass metabolism and the harmful acidic environment of the stomach that arises from oral drug absorption. Transdermal patches have garnered interest and been used for many years to treat a variety of illnesses and ailments. These medications include nitroglycerin, clonidine, nicotine, and fentanyl. This approach has also been investigated recently for the delivery of biologics in several applications. Here, we examine the body of research on the design

There are currently no clear cut guidelines available to help clinicians discern whether a chronic wound is infected or prone to infection. Similarly, there are no established guidelines to assist in determining when systemic antibiotics are necessary or how long they should be administered. This absence of widely recognized guidelines may result in the overuse and misuse of systemic antibiotics, potentially leading to adverse drug reactions and the emergence of multidrug-resistant bacteria. Introducing a straightforward tool for assessing infection risk in patients with chronic wounds could aid clinicians in deciding when systemic antibiotics are warranted and in ensuring their appropriate use, ultimately possibly curbing the overreliance on such medications. This study highlights the role of W.A.R. score as a wound infection prediction score.

Burns to the perineum and buttocks are difficult to heal for a number of reasons, including the constant threat of contamination and shear stress. Pathogens can easily penetrate the wound bed and induce systemic infection. Patients' recovery is further delayed by lengthy healing times, which increases their pain and psychological stress as a result of the injury. Though they are rare, significant burns to the lower trunk and lower limbs can also involve the external urethra, penis, labial tissues, anal opening, and distal rectal mucosa. In this case report, we discuss the management of perineal burn wounds in our center.

Partial and deep partial-thickness burn wounds present a difficult diagnosis and prognosis.Management of burn wound inflicted by the different physical and chemical agents require different regimes which are poles apart from the regimes used for any of the other traumatic wounds. In extensive burn, because of increased capillary permeability, there is extensive loss of plasma leading to shock while whole blood loss is the cause of shock in other acute wounds.Even though the burn wounds are sterile in the beginning in comparison to most of other wounds, yet, the death in extensive burns is mainly because of wound infection and septicemia, because of the immunocompromised status of the burn patients. Current techniques of burn wound care have significantly reduced the incidence of invasive burn wound infection, altered the organisms causing the infections that do occur, increased the interval between injury and the onset of infection, reduced the mortality associated with infection, decreased the overall incidence of infection in burn patients, and increased burn patient survival. Feracrylum, a water-soluble combination of partial ferrous salts (II and III) of polyacrylic acid, is one of the chemical hemostatic agents and an antibacterial agent. Its molecular weight ranges from 500,000 to 800,000 Daltons, which prevents systemic absorption and prevents any negative effects on the liver, kidney, adrenals, cardiovascular, or hemostatic systems. Feracrylum has antibacterial properties, which lowers the risk of wound infection.